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Description: Axolotl - the Mexican wonder healerResearch Field: Developmental and Evolutionary Biology/GeneticsA Mexican salamander is the world champion in regeneration. This primeval animal, called the axolotl, doesn’t care if one of its legs gets ripped off - as it will grow back in a matter of days. The same holds true for a lost tail, a part of its jaw, an eye, or even a piece of its heart.A team of scientists headed by Elly Tanaka at the Max Planck Institute for Cell Biology and Genetics in Dresden is taking a closer look at this astounding phenomenon. Their hope is to unveil the secrets of the axolotl for the benefit of mankind. After all, human beings are also capable of regenerating to a certain extent - for example, wound healing. The researchers believe that humans lost the ability to completely regenerate during the course of evolution. It is, however, possible that this ability has only been suppressed and could somehow be reactivated in the future.The researchers have already discovered the first messengers that reprogram cells in axolotls, allowing muscle or cartilage cells to be produced from nerve cells. However, it may still take decades until the results can also be applied to human beings. The Mexican salamander is therefore assured its status as world champion regenerator for years to come.Copyright: © Deutsche WellePublished at ScienceStage.com in cooperation with the Max Planck Society.Involved Institutes: Max Planck Institute of Molecular Cell Biology and Genetics
Abstract: Amphibians occupy a central position in phylogeny between aquatic and terrestrial vertebrates and are widely used as model systems for studying vertebrate development. We have undertaken a comprehensive molecular approach to understand the early even...
Abstract: The spastic mutant axolotl shows abnormal swimming behavior, which includes a preponderance of "embryonic" swimming elements (coils) versus mature swimming elements (sinusoids) and a failure to entrain sinusoids into a prolonged swimming sequence. Th...
Abstract: A method has been developed to establish the degree of cross-reactivity of an antiserum raised against purified carbamoyl-phosphate synthase (ammonia) from adult rat liver, toward a homologous enzyme from another species without purification of the l...
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Abstract: Favorable conditions for organ transplantation exist for some populations of European laboratory axolotls, making transplantations of heads possible. Survival of the transplants is prolonged because homograft reactivity of the host animals is absent....
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Abstract: MRC Centre for Developmental Neurobiology, King's College London, London, UK.
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Abstract: Three series of palette stage regenerates were prepared by amputating both arms of juvenile axolotls in the mid-forearm, above the elbow, or close to the shoulder. Within each series, excised regenerates were replaced in their original orientation (a...
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Abstract: The MHC of the urodele amphibian Ambystoma mexicanum consists of multiple polymorphic class I loci linked, so far as yet known, to a single class II B locus. This architecture is very different from that of the anuran amphibian Xenopus. The number of...
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Abstract: Cytological and autoradiographic studies were done to investigate the cytoplasmic control of DNA synthesis under conditions of physiological polyspermy. The DNA synthetic phases of the egg, principal sperm and accessory sperm nucleic were determined ...
Abstract: Fluorescent carbocyanine dye (diI) was used to label the glossopharyngeal (IX) nerve in the fixed preparation of the Mexican salamander, axolotl. When the cell bodies were viewed with a confocal laser scanning microscope and Nomarski optics, the cyto...