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Description: Prof Mariano Barbacid - Spanish National Cancer Centre, Madrid The problems of getting new molecules to the clinic Prof Mariano Barbacid of the Spanish National Cancer Centre, Madrid, interviewed by Prof Gordon mcvie, managing editor of ecancer, at ECCO 15 - ESMO 34, Berlin, 2009. Newer mouse models needed for testing drugs. Need to reduce failure rate of new drugs. Academia's role in drug development. Epigenetic targets.