George Wilding, MD, UW Carbone Cancer Center

On 17 January 1935 Lloyd George sought to promote a radical programme of economi...

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threat and joined Winston Churchill, among others, in fighting the government's ...

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Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the da...

In a new study, researchers at the Moores Cancer Center and Department of Family and Preventive Medi...

http://www.nucleusinc.com This 3D patient education medical animation depicts various surgical proce...

Cancer occurs when a single cell in the body stops performing its normal function and grows out of c...

In a new study, researchers at the UCSD School of Medicine and Moores Cancer Center used a complex c...

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Dr. Christian Sandrock of UC Davis Divisions of Infectious Diseases and Pulmonary and Critical Care ...

Fibroblast growth factors, or FGFs are a family of growth factors that are important for normal embr...

www.preop.com Patient ED @ 617-379-1582 INFO Your doctor has recommended that you undergo surgery to...

George Wilding is a Director of the Paul P. Carbone Comprehe...

Barbara Wilding, CBE, QPM, CCMI, FRSA is the Chief Constable...

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Author: George Wilding

Abstract: Despite much enthusiasm, no clear clinical benefit to any antiangiogenic agent has yet been demonstrated. Phase I trials demonstrate that endostatin, an endothelial cell toxin, can be administered safely, but no obvious anti-tumor effects were observ...

Author: George Wilding

Abstract: PURPOSE: We assessed the efficacy of the oral multitargeted tyrosine kinase inhibitor sunitinib in patients with metastatic clear cell renal cell carcinoma. MATERIALS AND METHODS: Patients with metastatic clear cell renal cell carcinoma were enrolled...

Author: George Wilding

Abstract: PURPOSE: Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. This Phase I, dose-escalation study was designed to e...

Author: A S WILDING WILDING

Abstract:

Author: George Wilding

Abstract: Advanced transitional cell carcinoma of the urothelium is an aggressive malignancy characterized by a median survival period of less than 1 year. Although this disease is moderately chemotherapy-sensitive, to the authors' knowledge the impact of ther...

Author: George Wilding

Abstract: PURPOSE: The objectives of this trial were to assess the maximal tolerated dose and toxicity of the combination of oral eniluracil and 5-fluorouracil and intravenous gemcitabine. PATIENTS AND METHODS: Patients with histologically confirmed, incurable...

Author: George Wilding

Abstract: PURPOSE: Flavopiridol (NSC 649890) is a synthetic flavone possessing significant antitumor activity in preclinical models. Flavopiridol is capable of inducing cell cycle arrest and apoptosis, presumably through its potent, specific inhibition of cycl...

Author: George Wilding

Abstract: PURPOSE: Testosterone administration can lead to increased antipyrine clearance in humans. Medical or surgical castration is a standard treatment of progressive prostate carcinoma, but the effect of the subsequent fall of testosterone concentrations ...

Author: George Wilding

Abstract: This Phase I study of 1alpha-hydroxyvitamin D(2), an p.o. administered vitamin D analogue, in patients with advanced hormone-refractory prostate cancer was designed to assess the toxicity, pharmacokinetic and biological markers of drug activity, and ...

Author: George Wilding

Abstract: INTRODUCTION: Chemotherapy regimens including gemcitabine in combination with microtubule inhibitors such as docetaxel and paclitaxel have wide clinical application. Patupilone is a novel tubulin-polymerizing agent with activity against paclitaxel-re...

Author: George Wilding

Abstract: OBJECTIVE: To assess the efficacy and toxicity of the combination of interferon-alpha and doxycycline in patients with metastatic renal cell carcinoma and to assess the effect of this treatment on serum vascular endothelial growth factor (VEGF) level...

Author: George Wilding

Abstract: PURPOSE: To assess the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacodynamics, and antitumor activity of continuous weekly-administered paclitaxel and BMS-214662, a novel farnesyl transferase inhibitor. EXPERIMENTAL DESIGN: Pati...

Author: George Wilding

Abstract: PURPOSE: This study determined the range of tolerable doses, clinical safety, pharmacokinetics, and preliminary evidence of clinical activity following once or twice daily administration of lapatinib in patients with solid malignancies. EXPERIMENTAL ...

Author: George Wilding

Abstract: PURPOSE: Endostatin is the first endogenous angiogenesis inhibitor to enter clinical trials. Laboratory investigations with endostatin have indicated broad antitumor activity coupled with remarkably low toxicity. A phase I trial of recombinant human ...

Author: George Wilding

Abstract: Penclomedine is a synthetic alpha-picoline derivative that has shown antitumor activity both in preclinical development and in Phase I work using an i.v. preparation. The main toxicities seen in those studies were dose dependent and mainly neurocereb...

Author: George Wilding

Abstract: Following the demonstration that the androgen activity of androsta-5-ene-3beta,17beta-diol (Adiol) is not inhibited by the anti-androgens currently used to treat prostate cancer, we sought agents that would inhibit the androgenic function of Adiol as...

Author: George Wilding

Abstract: BACKGROUND: Vitamin D has been suggested as a chemopreventive and therapeutic modality for prostate cancer. However, hypercalcemic toxicity has limited the use of 1alpha,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) in clinical trials, prompting the se...

Author: George Wilding

Abstract: PURPOSE: Flavopiridol is a cyclin-dependent kinase inhibitor with preclinical activity against prostate cancer cell lines. A Phase II trial was conducted to determine the activity of flavopiridol in patients with metastatic hormone-refractory prostat...

Author: George Wilding

Abstract: This was a single-agent phase II clinical trial of the antifol piritrexim in patients with advanced transitional cell carcinoma of the bladder. METHODS: Patients with previously-treated, advanced urothelial carcinoma were treated with oral piritrexim...

Author: George Wilding

Abstract: Antioxidants, such as vitamin E, are being investigated for efficacy in prostate cancer prevention. In this study, we show that the antioxidant moiety of vitamin E, 2,2,5,7,8-pentamethyl-6-chromanol (PMCol), has antiandrogen activity in prostate carc...