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Peter+Parnall
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- mRNA deadenylation by PARN is essential for embryogenesis in higher pl...
- Deadenylation of mRNA is often the first and rate-limiting step in mRNA decay. PARN, a poly(A)-specific 3' --> 5' ribonuclease which is conserved in many eukaryotes, has been proposed to be primarily ...
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Uploaded: 2004-7-13
- Expression and purification of recombinant poly(A)-specific ribonuclea...
- PARN is a poly(A)-specific ribonuclease that degrades the poly(A) tail of mRNA. We have established conditions for expressing soluble recombinant human PARN. We investigated different Escherichia coli...
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Uploaded: 2006-4-20
- Structural insight into poly(A) binding and catalytic mechanism of hum...
- Poly(A)-specific ribonuclease (PARN) is a processive, poly(A)-specific 3' exoribonuclease. The crystal structure of C-terminal truncated human PARN determined in two states (free and RNA-bound forms) ...
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Uploaded: 2005-11-11
- Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nuc...
- Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substra...
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Uploaded: 2008-9-3
- Analysis of ABA hypersensitive germination2 revealed the pivotal funct...
- Accumulating evidence suggests that mRNA degradation systems are crucial for various biological processes in eukaryotes. Here we provide evidence that an mRNA degradation system is associated with som...
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Uploaded: 2005-12-20
- Competitive inhibition of human poly(A)-specific ribonuclease (PARN) b...
- Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of g...
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Uploaded: 2009-8-14
- Genetic variation in open reading frame 5 gene of porcine reproductive...
- In an effort to understand the genetic variation in porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Taiwan, 40 isolates obtained between 2004 and 2006 were analyzed for their s...
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Uploaded: 2008-6-24
- Serum-deprivation stimulates cap-binding by PARN at the expense of eIF...
- PARN, a poly(A)-specific ribonuclease, binds the 5' cap-structure of mRNA and initiates deadenylation-dependent decay. Eukaryotic initiation factor 4E (eIF4E) also binds to the cap structure, an inter...
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Uploaded: 2005-1-18