One of the profound changes in cellular morphology during mitosis is a massive alteration in the organization of microfilament cytoskeleton. It has been recently discovered that nonmuscle caldesmon, a...
The micronuclear mitotic spindle of Tetrahymena pyriformis contains several distinctive elements. The 150 or so continuous microtubules (MTs) form a peripheral sheath just inside the inner nuclear mem...
At mitosis, focal adhesions disassemble and the signal transduction from focal adhesions is inactivated. We have found that components of focal adhesions including focal adhesion kinase (FAK), paxilli...
Based on the assumption that the ancestral proto-eukaryote evolved from an ameboid prokaryote I propose the hypothesis that nuclear division of the proto-eukaryote was effected by the same system of c...
Degradation of p53 requires transcription, and therefore inhibitors of transcription cause p53 accumulation. When transcription resumes, the p53 that accumulated in turn induces p21. During mitosis, c...
Mitosis-specific phosphorylation of caldesmon: possible molecular mechanism of cell rounding during mitosis.
Yamashiro S, Matsumura F.
Department of Molecular Biology and Biochemistry, Rutgers Unive...