Results for:
"
Metka+Krasovec&action
" in Documents
- Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and...
- Somatic KRAS mutation is an early well-known event in colorectal carcinogenesis but a complete understanding of RAS function and dysfunction in colorectal cancer is still to come. Our aim was to study...
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Uploaded: 2009-10-14
- KRAS mutation, KRAS-LCS6 polymorphism, and non-small cell lung cancer.
- The let-7 family of microRNAs are important regulatory molecules in lung cancer. One downstream target of let-7 is the RAS gene family, including KRAS, an important oncogene in the etiology and clinic...
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Uploaded: 2009-10-27
- No duplicate KRAS mutation is identified on the same allele in gastric...
- Codon 12 and 13 mutations in 170 colorectal cancer (CRC) and 66 gastric cancer (GC) specimens were analysed by an 'enriched' polymerase chain reaction-restriction fragment length polymorphism (PCR-RFL...
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Uploaded: 2007-8-19
- Transgenic mice carrying the human KRAS oncogene under the control of ...
- We have previously generated transgenic mice bearing a molecular construct obtained by fusing the rat thyroglobulin promoter with the human Kirsten ras oncogene (KRAS). These mice showed thyroid abnor...
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Uploaded: 1996-1-1
- Detection of N-, H-, and KRAS codons 12, 13, and 61 mutations with uni...
- OBJECTIVES: Mutations of all three RAS genes, N-, H-, and KRAS, are identified mainly in codons 12, 13, and 61 of exons 2 and 3 in human cancers. DESIGN AND METHODS: DNA samples were isolated from 58 ...
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Uploaded: 2009-11-3
- KRAS mutation profile in colorectal carcinoma and novel mutation--inte...
- Oncogenic KRAS mutations are associated with resistance to anti-EGFR therapy in colorectal carcinoma. Since anti-EGFR monoclonal antibodies are employed in clinical practice in advanced colorectal can...
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Uploaded: 2008-8-2
- KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab ...
- BACKGROUND: KRAS codons 12 and 13 mutations predict resistance to anti-EGFR monoclonal antibodies (moAbs) in metastatic colorectal cancer. Also, BRAF V600E mutation has been associated with resistance...
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Uploaded: 2010-8-18
- A novel method, digital genome scanning detects KRAS gene amplificatio...
- BACKGROUND: Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, howeve...
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Uploaded: 2009-12-16