Ecdysone metabolism was investigated in the white mouse Mus musculus. It was shown to involve dehydroxylation at C-14, followed by reduction of ring B into a 6 alpha-hydroxy derivative and epimerizati...
OBJECTIVE: We investigated whether differences in pharmacokinetics of midazolam, a CYP3A probe, could be demonstrated between subjects with different CYP3A4 and CYP3A5 genotypes. METHODS: Plasma conce...
Drug transporters are increasingly recognized as a key determinant of drug disposition and response. It is now widely appreciated that expression of the ATP-dependent efflux transporter, MDR1 (ABCB1, ...
This article outlines an evaluatory study of kerb negotiation in a conventional wheelchair and a prototype diamond configuration, lever articulated wheelchair. The kerb negotiation sequence in both mo...