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Joan+Brown
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- RHO SIGNALING in vascular diseases.
- Rho signaling pathways in vascular smooth muscle cells are highly activated in hypertension, a condition associated with a variety of vascular diseases, including restenosis injury and atherosclerosis...
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Uploaded: 2004-12-24
- Lipid signalling in cardiovascular pathophysiology.
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Uploaded: 2009-7-9
- Sphingosine-1-phosphate receptor signalling in the heart.
- The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit diverse tissue expression profiles and couple to distinct G-protein-mediated signalling pathways. S1P1, S1P2, and S1...
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Uploaded: 2010-5-1
- Do clinical practice guidelines improve processes or outcomes in prima...
- BACKGROUND: Clinical practice guidelines (CPGs) are common, but it is not clear whether they improve care. METHODS: Quality indicators for processes and outcomes of care were obtained from a computeri...
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Uploaded: 2005-4-15
- Ca2+ dysregulation induces mitochondrial depolarization and apoptosis:...
- We previously reported that constitutively activated Galpha(q) (Q209L) expression in cardiomyocytes induces apoptosis through opening of the mitochondrial permeability transition pore. We assessed the...
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Uploaded: 2005-8-3
- beta-Adrenergic receptor signaling in the heart: Role of CaMKII.
- The multifunctional Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) targets a number of Ca(2+) homeostatic proteins and regulates gene transcription. Many of the substrates phosphorylated by Ca...
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Uploaded: 2009-11-4
- G protein-coupled receptors go extracellular: RhoA integrates the inte...
- The identification of downstream effectors of G protein-coupled receptors (GPCRs) is critical for understanding the interactions between signaling cascades and for developing new pharmacological appro...
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Uploaded: 2008-10-3
- Upregulation of GLUT1 expression is necessary for hypertrophy and surv...
- During hypertrophy the heart increases its utilization of glucose and decreases that of fatty acids, resuming a fetal pattern of substrate metabolism. As demonstrated here, GLUT1 protein expression is...
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Uploaded: 2003-10-2