Biographical data on George Huntington, the 'discoverer' of Huntington's Chorea and George Sumner Huntington--a well-known American anatomist of the late 19th century and the first decades of the 20th...
OBJECTIVE: To determine the rate of functional decline in a large cohort of patients with Huntington's disease (HD) followed at 43 sites by the Huntington Study Group (HSG). METHODS: The annual rate o...
The mechanism by which polyglutamine expansion in Huntington's disease (HD) results in selective neuronal degeneration remains unclear. We previously reported that the immunohistochemical distribution...
The Unified Huntington's Disease Rating Scale (UHDRS) was developed as a clinical rating scale to assess four domains of clinical performance and capacity in HD: motor function, cognitive function, be...
Oxidative damage due to free-radical generation in the setting of underlying defects of neuronal energy metabolism has been implicated as a pathogenetic mechanism for Huntington's disease (HD). The au...
BACKGROUND: Since the first descriptions of chorea in the Middle Ages, medicine has been captivated by the mysterious appearance of patients suffering from contortions of the body. Many innocent victi...