Centrosomes contain a pair of centrioles that duplicate once during the cell cycle to give rise to two mitotic spindle poles, each containing one old and one new centriole. Centrosome duplication init...
Abstract
Summary form only as given. Polo International and SOFTEX 2000 in Brazil have established international technology assessment and marketing linkages in Europe, Asia, and the USA. Polo Intern...
Abstract
Summary form only as given. Polo International and SOFTEX 2000 in Brazil have established international technology assessment and marketing linkages in Europe, Asia, and the USA. Polo Intern...
Polo-like kinases (Plks) contain a conserved Polo-box domain, shown to bind to phosphorylated Ser-pSer/pThr-Pro motifs. The Polo-box domain of Plk-1 mediates substrate interaction and plays an importa...
Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In addition to the kinase domain, polo kinases have a strikingly conserved sequence in the noncatalytic domai...
Polo-like kinase-1 (Plk1) has a pivotal role in cell proliferation and is considered a potential target for anticancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 forms a phosphoepitope bi...
Playing polo: Small-molecule inhibitors of polo-like kinase 1 are mostly ATP-competitive, and thus face enormous specificity hurdles. This communication explores the concept of inhibiting Plk1 with a ...