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Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat

Fri, 01/22/2010 - 08:00 — sciencestaff

Background

In mammals, calories ingested in excess of those used are stored primarily as
fat in adipose tissue; consistent ingestion of excess calories requires an
enlargement of the adipose tissue mass. Thus, a dysfunction in adipose
tissue growth may be a key factor in insulin resistance due to imbalanced
fat storage and disrupted insulin action. Adipose tissue growth requires the
recruitment and then the development of adipose precursor cells, but little
is known about these processes in vivo.

Methodology

In this study, adipose cell-size probability distributions were measured in
two Zucker fa/fa rats over a period of 151 and 163 days, from four weeks of
age, using micro-biopsies to obtain subcutaneous (inguinal) fat tissue from
the animals. These longitudinal probability distributions were analyzed to
assess the probability of periodic phenomena.

Conclusions

Adipose tissue growth in this strain of rat exhibits a striking temporal
periodicity of approximately

days. A simple model is proposed for the periodicity, with
PPAR signaling driven by a deficit in lipid uptake capacity leading to the
periodic recruitment of new adipocytes. This model predicts that the
observed period will be diet-dependent.


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