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Skeletal Muscle Phenotypically Converts and Selectively Inhibits Metastatic Cells in Mice

Thu, 2010-02-18 09:00 — sciencestaff

Skeletal muscle is rarely a site of malignant metastasis; the molecular and cellular basis for this rarity is not understood. We report that myogenic cells exert pronounced effects upon co-culture with metastatic melanoma (B16-F10) or carcinoma (LLC1) cells including conversion to the myogenic lineage in vitro and in vivo, as well as inhibition of melanin production in melanoma cells coupled with cytotoxic and cytostatic effects. No effect is seen with non-tumorigenic cells. Tumor suppression assays reveal that the muscle-mediated tumor suppressor effects do not generate resistant clones but function through the down-regulation of the transcription factor MiTF, a master regulator of melanocyte development and a melanoma oncogene. Our findings point to skeletal muscle as a source of therapeutic agents in the treatment of metastatic cancers.


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    • skeletal muscle: Definition from Answers.com
      skeletal muscle n. A usually voluntary muscle made up of elongated, multinucleated, transversely striated muscle fibers, having principally bony
    • Why are skeletal muscle cells multinucleated
      Answer . They are myonucleated because during embryonic development, each skeletal muscle fiber arises from the fusion of myoblasts, which is how they form multinucleated ...
    • What is Skeletal muscle tonus
      The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent ...
    • Why are skeletal muscle striated
      Because muscle cells can only contract, not extend, skeletal muscles most work in pairs. While one muscle contracts, the other muscle in the pair relaxes to its original length.
    • What is the skeletal muscle function
      Skeletal muscles move the body; referred to as ambulation. There are 4 primary functions of skeletal muscle: 1. Movement 2. Posture or muscle tone
    • Why are skeletal muscle red
      Because muscles need a lot of ATP for muscle contraction and it needs oxygen to make ATP, it has its own form of hemoglobin called myoglobin. The binding of oxygen to hemo(myo ...
    • Microscopic anatomy of skeletal muscle
      1. Muscle 2. Strands/Bundles 3. Muscle Fibers (a.k.a. cells) 4. Sacrolemma (plasma membrane) 5. Sacroplasmic Reticulum (modified ER of cell / stores calcium / tubules that ...
    • What causes striations of skeletal muscle tissue
      Skeletal Muscle (as well as Cardiac Muscle) have striations do to their sarcomere's anatomy. The sarcomere is the functional unit of the muscle and appears striated because the ...
    • How does a skeletal muscle contract
      The brain sends electrical impulses to the muscles telling them to pull. Muscles extend and relax when the brain tells them not to pull or contract.
    • What are the striations in the skeletal muscle
      The striations that are evident in skeletal muscle are due to the areas between the sacromeres that is referred to as the Z-lines.

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