A granulocyte-macrophage colony–stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties

Suppression of the immune system could block autoimmune disease pathogenesis. Here Jacques Galipeau and his colleagues report that a fusion protein of two cytokines can induce immunosuppressive regulatory B cells. Transferring these cells into a mouse model of multiple sclerosis reduces disease in the mice.