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Nature Biotechnology

Sun, 2009-08-16 18:17 — sciencestaff

Covering the science and business of biotechnology.

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
Sensitive digital quantification of DNA methylation in clinical samples
Single-molecule sequencing of an individual human genome
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses
A proteomics approach to discovering natural products and their biosynthetic pathways
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
Automated design of synthetic ribosome binding sites to control protein expression
Induction of protein-protein interactions in live cells using light
Transcriptional analysis of intracytoplasmically stained, FACS-purified cells by high-throughput, quantitative nuclease protection
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells
High-resolution analysis of DNA regulatory elements by synthetic saturation mutagenesis
DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity
Direct photosynthetic recycling of carbon dioxide to isobutyraldehyde
A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner
Label-free, normalized quantification of complex mass spectrometry data for proteomic analysis
Building the sequence map of the human pan-genome
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

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