Tumor suppressor p53-binding protein 1 (53BP1) regulates the repair of dysfunctional telomeres lacking the shelterin protein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here, by blocking 5′ resection by CtIP. We report that these functions of 53BP1 required its N-terminal ATM/ATR target sites and...
50 Years AgoI wish to appeal to my fellow geologists and workers in the rapidly growing subject of geochronology to discontinue a habit or fashion which is both unnecessary and misleading. I refer to the habit of calling radiometric ages 'absolute' ages. An age
Five things you need to know about ABC News' new iPad app.
Retailers keep demanding higher productivity from existing workers while trimming staff to save costs.
In April, the unemployment rate fell to 8.1%. But according to the Bureau of Labor Statistics data, experts say the outlook would be far rosier if it weren’t for a handful of sectors dragging down job growth.
According Bureau of [...]
Over the past few months, I've been thinking more than ever about what it takes to make it in business.
50 Years AgoCharles Darwin's Orchid Bank at Downe in Kent has recently been acquired as a nature reserve by the Kent Naturalists' Trust. It is a site of great scientific interest which shows a wide range of vegetation types ... and, as it is
Terrie E. Moffitt, Louise Arseneault, Daniel Belsky, Nigel Dickson, Robert J. Hancox, HonaLee Harrington, Renate Houts, Richie Poulton, Brent W. Roberts, Stephen Ross, Malcolm R. Sears, W. Murray Thomson, Avshalom CaspiFeb 15, 2011; 108:2693-2698Social Sciences
Larry Pederson, Ming Ruan, Jennifer J. Westendorf, Sundeep Khosla, Merry Jo OurslerDec 30, 2008; 105:20764-20769Cell Biology