The microRNA-183/96/182 cluster is highly expressed in the retina and other sensory organs. To uncover its in vivo functions in the retina, we generated a knockout mouse model, designated “miR-183CGT/GT,” using a gene-trap embryonic stem cell clone. We provide evidence that inactivation of the cluster results in early-onset and progressive...
Imagine you are given $100.00. You have to propose how to share the money with another person, who can accept, in which case both earn as you have proposed, or reject your offer, in which case neither player gets anything. If both are rational maximizers, the proposer offers one cent,...
We recently showed that genes with worker-biased expression have high guanine–cytosine (GC) content and genetic diversity (1). Hunt et al. (2) conduct additional analyses, which are interesting but do not alter our conclusions (1).Hunt et al. (2) replicate our findings (1) on the association between GC content and worker-biased genes...
Kent et al. (1) recently investigated genome evolution in the honey bee and proposed “strong links between recombination, biased gene conversion, GC-content evolution, and worker behavior.” However, we feel these connections may be more nuanced than suggested.Kent et al. (1) illustrated dramatically higher guanine and cytosine (GC) content for worker-biased...
What is meant by ‘science’? How do political, philosophical and religious beliefs affect scientific discoveries and developments? In this unit you focus on your own experiences and knowledge of science, and you look at creative contexts to support children’s scientific learning in primary schools and early years settings.
