Everyone has heard of hindsight - where the context of past events is much clearer in memory than they were at the time - but a new study of the blindsight phenomenon, where a person is cortically blind yet they can still discriminate visual information without any awareness, could make the architecture of the brain a lot clearer.
(Ohio Supercomputer Center) Surveying the wide range of parallel system architectures offered in today's supercomputer market, a graduate student at the Ohio State University, Saniyah Bokhari, recently established some side-by-side performance comparisons.
Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on the host cellular machinery to replicate. Identifying which host proteins and complexes come into physical contact with the viral proteins is crucial for a comprehensive understanding of how HIV rewires the host’s cellular machinery during the course of infection.
Determination of the proteasome regulatory particle structure by electron microscopy.
Ribosome profiling reveals specialized translation of the prostate cancer genome by oncogenic mTOR signalling; stringent inhibition of mTOR signalling reduces prostate cancer invasion and metastasis in a mouse model.
Using a combination of chromosome conformation capture carbon copy (5C), three-dimensional modelling and live cell imaging, the authors were able to resolve the three-dimensional architecture of the Caulobacter crescentus bacterial genome. They show the genome to be ellipsoidal with periodically arranged chromosome arms. The
Although half of the human genome is derived from retrotransposons, mobilization of these elements is normally suppressed in somatic cells. By applying their newly developed, high-throughput method for detecting retrotransposon insertion sites (called retrotransposon capture sequencing (RC-seq)), Baillie and colleagues now show that L1, Alu
Across Africa, Asia, Latin America and
the United States, groundbreaking work is being done by small teams of outstanding professionals who
are helping communities to recover ...05.10.2011
by Denyse O'Leary
A disintegrin and metalloproteinase 10 (ADAM10) is a zinc-dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. We have developed B cell-specific ADAM10-deficient mice (ADAM10B–/–).