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Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma [Medical_Sciences]
Kaposi's sarcoma (KS) is an enigmatic vascular tumor thought to be a consequence of dysregulated expression of the human herpesvirus-8...
Cardioprotection by a nonerythropoietic, tissue-protective peptide mimicking the 3D structure of erythropoietin [Medical_Sciences]
Erythropoietin (EPO), originally identified for its critical hormonal role in regulating production and survival of erythrocytes, is a member of...
Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo [Medical_Sciences]
A high plasma urate concentration (PUA), related to loss of urate oxidase in evolution, is postulated to protect humans from...
Bone marrow transplantation restores epidermal basement membrane protein expression and rescues epidermolysis bullosa model mice [Medical_Sciences]
Attempts to treat congenital protein deficiencies using bone marrow-derived cells have been reported. These efforts have been based on the...
Identification of a microRNA signature of renal ischemia reperfusion injury [Medical_Sciences]
Renal ischemia reperfusion injury (IRI) is associated with significant morbidity and mortality. Given the importance of microRNAs (miRNAs) in regulating...
Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST) [Medical_Sciences]
Although gastrointestinal stromal tumors (GISTs) harboring activating KIT or platelet-derived growth factor receptor A (PDGFRA) mutations respond to treatment with...
Myocytic androgen receptor controls the strength but not the mass of limb muscles [Medical_Sciences]
The anabolic effects of androgens on skeletal muscles are thought to be mediated predominantly through the androgen receptor (AR), a...
D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms [Medical_Sciences]
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53, conferring tumor development...
Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters [Medical_Sciences]
Mitochondrial networks in cardiac myocytes under oxidative stress show collective (cluster) behavior through synchronization of their inner membrane potentials (m)....
Inhibition of Wnt/{beta}-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis [Medical_Sciences]
Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids...
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