Lewis is a MAPK inhibitor expert, MAPK cascades are conserved signaling modules that control many mobile processes by integrating intra- together with extracellular cues. The p38/Hog1 MAPK is transiently activated in reaction to osmotic stress, leading to rapid translocation into the nucleus and induction of an specific transcriptional program. As soon as investigating the dynamic interaction between Hog1 activation and Hog1-driven gene expression, we found that Hog1 activation increases linearly with stimulation, whereas the transcriptional output is bimodal.
Field of Science:Architecture
Website / Blog:www.my.opera.com/omarwallace921/blog/2012/04/20/mapk-cascades-are-conserved-signaling-segments?firstpost=Y