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The histamine H4 receptor is, like the other three histamine receptors, a member of the G protein-coupled receptor superfamily. H4 is highly expressed in bone marrow and white blood cells and regulates zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model along with L-selectin. It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea. They have been shown to mediate mast cell chemotaxis. It seems to do this by the mechanism of Gi-coupled decrease in cAMP.
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News
- Exposure to common environmental bacteria may be source of some allergic inflammation
( Federation of American Societies for Experimental Biology ) Could some cases of asthma actually be caused by an allergic reaction to a common environmental bacteria? New research findings published in the Journal of Leukocyte Biology suggests that this idea may not be as far-fetched as it seems. - Certain strains of P. aeruginosa cause WBCs to produce high levels of histamine
Could some cases of asthma actually be caused by an allergic reaction to a common environmental bacteria? New research findings published in the Journal of Leukocyte Biology suggests that this idea may not be as far-fetched as it seems. In a research report appearing in the February 2012 print issue, researchers show a link between common environmental bacteria and airway inflammation. - Exposure to common environmental bacteria may cause asthma
Washington, Feb 1 : Some cases of asthma may actually be caused by an allergic reaction to a common environmental bacteria, a new research has suggested. - Overdose killed student, police say
STONE, England, Jan. 18 (UPI) -- An 18-year-old British student died from an overdose of anti-histamine tablets, Staffordshire, England, investigators say. - Horizon Pharma Modifies DUEXIS(R) Marketing Authorization Application to Include Recently Approved Manufacturing Site
DEERFIELD, IL-- - Horizon Pharma, Inc. today announced that it has modified the DUEXIS® Marketing Authorization Application submission to the National Procedure in the United Kingdom to include the recently ... - Pill made from dust mites may help treat asthma sufferers
Washington, Feb 1 (ANI): A pill made from a protein found in dust mites may provide relief for asthma sufferers, scientists believe. - Pill made from dust mites may provide relief for asthma sufferers
A pill made from a protein found in dust mites could revolutionize asthma treatment, scientists reported Tuesday - Mind governs skin's reactivity to allergies
Sydney, Jan 19 (IANS) A harmonious mind-body connect, the key to good health, also seems to determine how your skin reacts to allergies. - Stomach Acid Drugs Increase Risk of Bacterial Infections, FDA Warns
The Food and Drug Administration is warning consumers today that certain stomach acid drugs may increase the risk of a serious intestinal bacteria infection. - Darpa Implants Could Track Your Stress Level 24/7
Plenty of geeks are already obsessed with self-tracking , from monitoring sleep rhythms to graphing caffeine intake versus productivity. Now, the Department of Defense’s far-out research agency is after the ultimate kind of Quantified Self : Soldiers with implanted body sensors that keep intimate tabs on their health, around the clock.
Related on Wikipedia
- Histamine - Wikipedia, the free encyclopedia
Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter Histamine ... - Histamine receptor - Wikipedia, the free encyclopedia
The histamine receptors are a class of G protein-coupled receptors with histamine as their endogenous ligand. There are four known histamine receptors: - Histamine antagonist - Wikipedia, the free encyclopedia
A histamine antagonist (commonly called an antihistamine) is a pharmaceutical drug that inhibits the action of histamine by blocking it from attaching to histamine receptors ... - Histamine agonist - Wikipedia, the free encyclopedia
A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes. Betahistine is an example used to treat vertigo. - Histamine H1 receptor - Wikipedia, the free encyclopedia
The H 1 receptor is a histamine receptor belonging to the family of Rhodopsin like G-protein-coupled receptors. This receptor, which is activated by the biogenic amine ... - H2 antagonist - Wikipedia, the free encyclopedia
The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. - H1 antagonist - Wikipedia, the free encyclopedia
An H 1 antagonist is a histamine antagonist of the H 1 receptor that serves to reduce or eliminate effects mediated by histamine, an endogenous chemical mediator released ... - Basophil granulocyte - Wikipedia, the free encyclopedia
Basophil granulocytes, sometimes referred to as basophils, are the least common of the granulocytes, representing about 0.01% to 0.3% of circulating white blood cells. - Ranitidine - Wikipedia, the free encyclopedia
Ranitidine ( / r ə ˈ n ɪ t ɨ d iː n /; trade name Zantac) is a histamine H 2-receptor antagonist that inhibits stomach acid production. It is commonly used in treatment of ... - Mast cell - Wikipedia, the free encyclopedia
A mast cell (also known as mastocyte and labrocyte) is a resident cell of several types of tissues and contains many granules rich in histamine and heparin.