Group - Thyroid hormone receptor alpha

 


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Thyroid hormone receptor alpha (TR-alpha) (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), also known as NR1A1 (nuclear receptor subfamily 1, group A, member 1), is nuclear receptor protein encoded by the THRA gene. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. THR1 has been shown to interact with NCOA6, MED16, MEF2A, TRIP11, MED1, ITGB3BP, MED6, COPS2, EP300, MED12 and UBC.  



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