Clinical study on acute kidney injury after myeloablative allogeneic hematopoietic cell transplantation

Based on these research results, the University of Michigan Comprehensive Cancer Center will soon be...

Kenneth J. Pienta, MD, director of U-Ms Michigan Institute for Clinical and Health Research, explain...

Dr. Harry Keyserling, professor of pediatric infectious diseases at Emory School of Medicine, gives ...

nurse. After graduating from Royal Victoria Hospitals school of nursing in Montreal in 1969, Monica ...

nurse. After graduating from Royal Victoria Hospitals school of nursing in Montreal in 1969, Monica ...

nurse. After graduating from Royal Victoria Hospitals school of nursing in Montreal in 1969, Monica ...

Dr. Mark Mulligan, MD, executive director of the Hope Clinic of the Emory Vaccine Center comments on...

Introduction to Psychology (PSYC 110) Professor Paul Bloom welcomes students and presents the course...

Introduction to Psychology (PSYC 110)Professor Paul Bloom welcomes students and presents the course ...

Introduction to Psychology (PSYC 110) Professor Paul Bloom welcomes students and presents the course...

In drug development, a covered clinical study refers to a cl...

In drug development, a covered clinical study refers to a cl...

Sub-clinical is a medical term referring to a disease proces...

Clinical ecology was the name given by proponents in the 196...

Clinical surveillance (or Syndromic surveillance) refers to ...

Clinical pathways, also known as care pathways, critical pat...

Clinical Professor is an academic appointment to a member of...

In a clinical research trial, a clinical endpoint refers to ...

Clinical significance was first proposed by Jacobson, Follet...

A single-agent dose-escalating phase I study on the novel sulfonamide E7070 was performed to determine the toxicity profile and the recommended dose for phase II studies. The pharmacokinetic profile of E7070 was also determined. E7070 was administered as a continuous infusion over 5 days repeated every 3 weeks. 27 patients were treated at doses ranging from 6 to 200 mg/m(2)/day. As with other administration schedules, the dose-limiting toxicities were dose-dependent, reversible neutropenia and thrombocytopenia. Although no objective responses w...

We evaluated clinical efficacy of recombinant human granulocyte colony stimulating factor (rG-CSF), successfully expressed in Chinese hamster ovarian cell, in gynecological tumor patients (pts) with neutropenia due to chemotherapy (CT). Fifty-eight pts with advance or relapsed gynecological malignancy were entered into this study. These pts had neutropenia below 1,000/cmm by CT and in the next cycle of CT they were treated with daily rG-CSF (2 micrograms/kg/day, subcutaneously) starting from the next day of CT for 14 days. The activities of rG-...

Didemnin B (NSC-325319), a new depsipeptide isolated from a Caribbean tunicate, has been evaluated in a clinical phase I study. The drug was administered in a schedule of a 4 weekly intravenous injection in a six-weeks cycle. Fifty-three patients received 71 evaluable cycles in an escalated dose ranging from 0.4 mg/m2/week to 2.5 mg/m2/week. No hematological toxicity was demonstrated at any dose level. Without prophylactic antiemetics nausea and vomiting was dose limiting at 1.2 mg/m2/week. Due to the use of Cremophor EL as a solvent, hypersens...

[A clinical study of recombinant human G-CSF in gynecological tumor patients with neutropenia due to chemotherapy (rG.CSF Clinical Study Group)] [Article in Japanese] Terashima Y, Ochiai K, Hashimoto M, Nishiya I, Takamizawa H, Hasumi K, Takada M, Akiya K, Negishi Y, Takeda Y, et al. Department of Obstetrics and Gynecology, Jikei University School of Medicine. We evaluated clinical efficacy of recombinant human granulocyte colony stimulating factor (rG-CSF), successfully expressed in Chinese hamster ovarian cell, in gynecological tumor ...

In the second part of the paper on isoelastic cervicocapital prostheses the authors describe a group of patients with an implanted endoprosthesis. The selection of indication for implantation was very strict and the group of patients is very homogeneous. The endoprosthesis was implanted to biologically old patients with fractures of the neck of the femur where it was not possible to select treatment other than implantation of a cervicocapital prosthesis. The group of patients was evaluated subjectively according to a questionnaire sent to the f...

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study, recently published in the New England Journal of Medicine, demonstrated a highly significant cardiovascular protection by an angiotensin converting enzyme inhibitor, ramipril at a dose of 10 mg/day, after a mean follow-up of 4.5 years, but not of vitamin E supplements at a dose of 400 UI/day in high-risk patients (> 55 years old) who had evidence of vascular disease (secondary prevention) or combined diabetes mellitus and another cardiovascular risk factor (primary preventi...

The study of the health impact of dietary Maillard products (MPs) in realistic clinical studies requires the design of nutritionally equivalent diets with high and low levels of MPs. This difficult challenge may be achieved by setting the high-MP diet at the regular daily level, where the common use of grilling, frying, and roasting processes allows significant amounts of carboxymethyllysine, hydroxymethylfurfural and acrylamide to be formed. In such conditions, we show that major lipid degradation does not occur, nor does degradation of vitami...