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Abstract: [Cholera in Bergen in 1848-1849--what caused the epidemic?] [Article in Norwegian] Oedi ng P. Avdeling for mikrobiologi og immunologi, Gades Institutt, Universitetet i Bergen. In December 1848, a big cholera epidemic broke out in Bergen. It lasted until April 1849, by which time 605 victims had died. The cholera spread by contact from person to person. How it came to Bergen, and how it was introduced into the population however, been open to doubt. This question is subject of this article. Primary sources have been studied and compared with contemporary medical reports. There is no doubt that a schooner from the Dutch city of Vlaardingen brought the cholera to Bergen. A passenger died of cholera on the day before the ship arrived, and was buried in Bergen. How the infection was transmitted to the first victim in the city, a watchman's wife who lived on the outskirts, is more difficult to explain. Later information, telling that she had washed the passenger's clothing, has not been confirmed in the primary sources. Most probably, healthy carriers among the crew transmitted the cholera to the population after the quarantine had been suspended. The watchman's wife need not have been the first one to catch the infection. PMID: 1523661 [PubMed - indexed for MEDLINE]
The recent development of safe, reasonably effective oral cholera vaccines has made it possible to consider their use in situations where the risk of epidemic cholera is high. This article reviews the potential cost-effectiveness of the B-subunit killed whole-cell (BS-WC) oral cholera vaccine in both a stable refugee population and a population with endemic cholera. Baseline epidemiologic assumptions were applied to the standard populations to generate the expected morbidity and mortality levels for cholera and simple diarrhea; then, the net co...
The importance of antibodies to cholera toxin (CT) versus desensitization of intestinal adenylate cyclase for protection against experimental cholera in the rat was investigated. Animals were immunized five times with CT either perorally or intravenously; antitoxic antibodies were measured in both serum and bile, and intestinal anti-CT-containing plasma cells (ACC) as well as eosinophilic leucocytes were counted. Both peroral and intravenous immunizations induced high levels of serum antibodies, while antibodies in bile appeared only after pero...
Pure cholera toxin (CT) given as a booster in enteric-coated tablets to rats produced a humoral and intestinal immune response similar to the result of instilling the boosting dose of CT directly into the duodenum. This method protects the antigen against gastric acid and allows delivery of the immunogen to intestinal mucosa, an essential step in producing intestinal secretory IgA. Immunization gave protection against pure CT during intestinal perfusion but also significantly protected against the secretory effects of E. coli LT and CT-like tox...