Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity 2 A genetic study of spontaneous and immunization-induced eosinophilia
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PubMed
(0) (0 Votes)Views: (1030) Date: (13-03-09) Pages: () -
Author: Winthereik MP Sp?rck JV Lundberg L Sompolinsky D.
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Abstract: Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity. 2. A genetic study of spontaneous and immunization-induced eosinophilia. Winth ereik MP, Sp?rck JV, Lundberg L, Sompolinsky D. Institute of Medical Microbiology, University of Copenhagen, Denmark. In 4 inbred strains of guinea pig the tendency to develop peripheral high-eosinophilia was shown to be genetically controlled. The development of eosinophilia with age and following immunization was examined in high- and low-eosinophilic parental strains, in F1-hybrids and in backcross offspring. The results show that probably only one or a very few segregating genes control eosinophilia, and they also indicate that different genes are involved in the determination of spontaneous (age-related) and immunization-induced eosinophilia. PMID: 1514667 [PubMed - indexed for MEDLINE]
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