Baseline and apomorphine-induced extracellular levels of nigral substance P are increased in an animal model of Parkinson s disease

A baseline is a line that is a base for measurement or for c...

Beginning as a video artist, Basque musician Pilar Baizán b...

In pharmacology and matters of biochemistry, baseline descri...

The Baseline Killer (or Baseline Rapist) was one of the two ...

Shifting baseline (also known as sliding baseline) is a term...

A baseline is the line from which the seaward limits of a St...

A baseline in medicine is information found at the beginning...

Baseline magazine is a magazine devoted to typography, book ...

A baseline is an important concept in budgeting, in particul...

IT baseline protection signifies standard security measures ...

The accurate evaluation of cardiovascular reactions to psychological challenge requires stable baselines against which change can be evaluated. When more than one challenge is employed, the recovery of this baseline becomes important in order to avoid carryover effects. Resting periods, even those of 20 min or more, do not guarantee baseline stability. We compared a 20-min resting condition and a new form of baseline condition in 48 college men using video tasks as the psychological challenges. The new form was a minimally demanding color detec...

Phase I thorough QT (TQT) studies are routinely conducted by pharmaceutical companies for all new compounds to satisfy the requirements of International Conference on Harmonisation (ICH) E14 guidance on the evaluation of QTc prolongation. The primary endpoint is the change from baseline in QT interval corrected for heart rate (QTc), and the hypothesis of interest is the noninferiority of drug to placebo. Sometimes, due to the properties of the compound, it becomes necessary to use parallel group designs for TQT studies. In such situations, the ...

'Baseline' estimation is of fundamental importance in both visual and numerical analysis of fetal heart rate recordings, even though the baseline itself is in reality an imaginary line. Here we describe a linear method of estimating baseline in fetal heart rate recordings. The method is easy to implement on a digital computer, and is capable of precise mathematical analysis. Non-linear methods, on the other hand, introduce unpredictable and non-quantifiable statistical bias, and are best avoided.

Abstract This paper describes the evaluation of a GPS-based remote system for the calibration of precision clocks. Experiments were conducted using multi-channel GPS receivers. Results of zero baseline-common clock and short baseline-common clock common view measurements show that these receivers are suitable for remote calibrations after the correction of delays associated with the measurements

The possibility of recovering earth rotation and network geometry (baseline) parameters are emphasized. The numerical simulated experiments performed are set up in an environment where station coordinates vary with respect to inertial space according to a simulated earth rotation model similar to the actual but unknown rotation of the earth. The basic technique of VLBI and its mathematical model are presented. The parametrization of earth rotation chosen is described and the resulting model is linearized. A simple analysis of the geometry of th...

The possibility of recovering earth rotation and network geometry (baseline) parameters are emphasized. The numerical simulated experiments performed are set up in an environment where station coordinates vary with respect to inertial space according to a simulated earth rotation model similar to the actual but unknown rotation of the earth. The basic technique of VLBI and its mathematical model are presented. The parametrization of earth rotation chosen is described and the resulting model is linearized. A simple analysis of the geometry of th...

In randomized clinical trials, a pre-treatment measurement is often taken at baseline, and post-treatment effects are measured at several time points post-baseline, say t=1, ..., T. At the end of the trial, it is of interest to assess the treatment effect based on the mean change from baseline at the last time point T. We consider statistical methods for (i) a point estimate and 95 per cent confidence interval for the mean change from baseline at time T for each treatment group, and (ii) a p-value and 95 per cent confidence interval for the bet...

The possibility of recovering earth rotation and network geometry (baseline) parameters are emphasized. The numerical simulated experiments performed are set up in an environment where station coordinates vary with respect to inertial space according to a simulated earth rotation model similar to the actual but unknown rotation of the earth. The basic technique of VLBI and its mathematical model are presented. The parametrization of earth rotation chosen is described and the resulting model is linearized. A simple analysis of the geometry of th...

Abstract This paper describes the evaluation of a GPS-based remote system for the calibration of precision clocks. Experiments were conducted using multi-channel GPS receivers. Results of zero baseline-common clock and short baseline-common clock common view measurements show that these receivers are suitable for remote calibrations after the correction of delays associated with the measurements

The possibility of recovering earth rotation and network geometry (baseline) parameters are emphasized. The numerical simulated experiments performed are set up in an environment where station coordinates vary with respect to inertial space according to a simulated earth rotation model similar to the actual but unknown rotation of the earth. The basic technique of VLBI and its mathematical model are presented. The parametrization of earth rotation chosen is described and the resulting model is linearized. A simple analysis of the geometry of th...

PURPOSE: The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. METHODS: We performed a retrospective analysis of alanine transaminase (ALT) levels in 481 placebo-treated healthy volunteers from 20 phase I trials by examining ALT elevation rates using the upper limit of normal values (ULN) as the cutoff as well as changes from baseline in actual ALT values. RESULTS: The ULN for ALT...

NASA's Crustal Dynamics Project (CDP) has the objective to improve the understanding of geodynamics by measuring crustal deformation, tectonic motion, and polar motion and earth rotation. Three different approaches are utilized for obtaining these measurements. One is based on satellite laser ranging (SLR), while another makes use of very long baseline interferometry (VLBI) which uses reception of radio signals from quasars. The third approach involves laser ranging to the moon. An important part of the CDP is to compare baselines periodically ...

NASA's Crustal Dynamics Project (CDP) has the objective to improve the understanding of geodynamics by measuring crustal deformation, tectonic motion, and polar motion and earth rotation. Three different approaches are utilized for obtaining these measurements. One is based on satellite laser ranging (SLR), while another makes use of very long baseline interferometry (VLBI) which uses reception of radio signals from quasars. The third approach involves laser ranging to the moon. An important part of the CDP is to compare baselines periodically ...

An investigation is conducted in order to expose errors in the formula for the elevation angle dependence of the hydrostatic atmospheric propagation delay, called the mapping function. A series of special VLBI experiments that involve a large fraction of group delay data from very low elevation angles are performed. Twenty-two experiments, each 26 hours in duration, were performed using VLBI antennas at Goldstone, California and at Westford, Massachusetts. Elevation angle cutoff tests were used to examine the contribution of these errors to the...