Drug interactions involving immunologic agents Part II Immunodiagnostic and other immunologic drug interactions


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    • Author:  Grabenstein JD.  

    • Abstract:  Drug interactions involving immunologic agents. Part II. Immunodiagnostic and other immunologic drug interactions. Grabe nstein JD. Pharmacy Service, U.S. Army Hospital-Bremerhaven , West Germany. This two-part review addresses pharmacists' need for information about immunologic drug interactions. Reports of interactions involving vaccines, immune globulins, and immunodiagnostic reagents are widely dispersed and, therefore, difficult to access. In the conclusion of this two-part article, immunodiagnostic drug interactions as well as interactions involving interferons and other biologic-response modifiers are discussed, as are epinephrine interactions that affect treatment of immunologic-induced anaphylaxis. Host factors of groups and individuals relating to the clinical significance of proposed interactions are covered, such as those involving influenza vaccine with theophylline, warfarin, or phenytoin, and other combinations. Vigilance by all pharmacists is needed to detect previously unreported immunologic drug interactions and further assess known interactions. PMID: 1689921 [PubMed - indexed for MEDLINE]

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