The recombinant human interferon-gamma receptor is fully functional in a human x murine hybrid containing human chromosome 21


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    • Author:  Bono MR  Alca?de-Loridan C  Letouz? B  Jouin H  Gobin SJ  Fellous M.  

    • Abstract:  The recombinant human interferon-gamma receptor is fully functional in a human x murine hybrid containing human chromosome 21. Bono MR, Alca?de-Loridan C, Letouz? B, Jouin H, Gobin SJ, Fellous M. Institut National de la Sant? et de la Recherche M?dicale U.276, Paris, France. It has previously been shown that stimulation of class I MHC antigen expression by human interferon gamma (Hu-IFN gamma) depends on the presence of both human chromosomes 6 and 21. Even although the presence of human chromosome 6 results in normal expression of the IFN gamma receptor on the cell surface, chromosome 21 is required for this biological response. Here, we transfected the cDNA encoding the Hu-IFN gamma receptor into a mouse cell line, L(tk-), and into a mouse x human hybrid, GM08, containing the human chromosome 21 as the only human genetic material. Two clones, L-gamma R.8 and GM08-gamma R.9, were tested for different biological responses to Hu-IFN gamma. Only the hybrid containing the human chromosome 21 (GM08-gamma R.9) exhibited a biological response when assayed for the stimulation of murine class I MHC antigen expression by Hu-IFN gamma. Moreover, transcriptional induction of 2'-5'-oligoadenylate synthetase and 1-8 genes, as well as antiviral protection, were observed only in the GM08-gamma R.9 transfectants. These results show that human chromosome 21 encodes a factor which mediates different biological activities of Hu-IFN gamma. PMID: 1665572 [PubMed - indexed for MEDLINE]

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