Is synaptic potentiation necessary for the development of kindling


     Related Videos

     Related Hubpages

    Field: Medicine  DOWNLOAD  BOOKMARK REPORT
    •  Doc. Url:    Embed Code: 

    • PubMed  status
      (0) (0 Votes)
      		Views: (1015)   Date: (27-01-09)   Pages: ()

    • Author:  Maru E.  

    • Abstract:  Is synaptic potentiation necessary for the development of kindling? Maru E. Department of Physiology, Nippon Medical School, Tokyo, Japan. Field potentials were recorded from the dentate gyrus of freely moving rats to examine the role of synaptic potentiation in the development of seizure susceptibility during rapid kindling. Kindling stimulations (10 Hz for 10 sec) were delivered to the perforant path at every 5 min for 5 or 6 hrs. This procedure produced a sustained depression of excitatory synaptic transmission at the perforant path-granule cell synapse during and after kindling. However, the kindling procedure resulted in the prolongation of afterdischarges and the development of interictal discharges originated from granule cells, indicating an increase in the seizure susceptibility of these neurons. These results indicate that synaptic potentiation is not a critical requirement for an increase in seizure susceptibility during rapid kindling, even if it has a facilitating effect on the development of kindling as suggested in previous studies. PMID: 1662303 [PubMed - indexed for MEDLINE]

         Related Documents

           Related Groups

             Related Science News

             More on Sciencestage

             Answers

             News
        • Is an Arab Spring in the air for Algeria?
          ALGIERS (Reuters) - When Moncef Marzouki, a former dissident transformed by the "Arab Spring" into Tunisia's president, paid an official visit to Algeria on Sunday, red and white Tunisian flags flew from lamp-posts in his honor. Just two days earlier, another former dissident and leading figure of Tunisia's revolution had been barred from entering. Sihem Bensedrine was allowed into the country ...
        • Space Is Dirty, and the Swiss Are Cleaning It Up
          Space is a dirty place. Over 16,000 pieces of debris over 10 cm wide have been left behind since Sputnik took to the skies in 1957. And now the Swiss want to do something about it. Scientists with the Swiss Space Center at the ??cole Polytechnique Federale de Lausanne (EPFL), Switzerland, are developing a "janitor" satellite, known as CleanSpace One, to make space tidier.
        • Wallenda's Niagara Falls tightrope walk is a go
          Daredevil Nik Wallenda is set to walk a 1,800 foot tightrope across Niagara Falls this summer, a feat the seventh-generation member of the famed Flying Wallendas said has been his childhood dream.
        • Jeremy Lin: 'Linsanity' Is a Booming Business
          Jeremy Lin is no longer just a basketball sensation. The New York Knicks star also has become a global business phenomenon.
        • St. Anthony is coming to town
          Carson Puriefoy is Bishop Eustace Prep's point guard.
        • Is this the end for the Flying Kangaroo?
          TRAVEL editor Brian Crisp looks at the issues facing Australia's flagship carrier following today's dramatic announcements.
        • Is Groupon Germany Taking on Amazon?
          This could be the calm before the storm, or at least the prizefighter that is Groupon telegraphing its first big moves for 2012. The always eagle-eyed Techcrunch.com has spotted that Groupon's German outpost...
        • Mr Pipeline thinks Olympic surfing is swell idea
          SYDNEY (Reuters) - With millions of people from Norway to Nantucket taking up surfing it is high time the sport was given a place at the Olympic Games, says revered Hawaiian surfer Gerry Lopez.
        • Arizona is Romney's to lose, Santorum threatens
          PHOENIX (Reuters) - Republican Mitt Romney faces a new challenge in Arizona's February 28 presidential primary, where the growing momentum of rival Rick Santorum could threaten to derail what had been an expected romp for the on-again, off-again front-runner. Romney was counting on Arizona to be his safety net as he fell behind Santorum in polls nationally and in his native state of Michigan ...
        • For London Youth, Down and Out Is Way of Life
          The lack of opportunity is feeding a mounting alienation and anger among young people across Europe, threatening to poison the aspirations of a generation.

             Related on Wikipedia




























         

        Powered free by PHPmotion