Study of non-opioid analgesics tolerance in young and adult rats.


     Related Videos
Study in Europe
  • Study in Europe

  • www.study-in-europe.org Europe is a fascinating place to study. But which country should you go to? ...

Study in Europe
  • Study in Europe

  • www.study-in-europe.org Europe is a fascinating place to study. But which country should you go to? ...

So you want to study at Edinburgh?
Somali Y chromosome study
Use of the Kinesiograph in the Study of Jaw Movements

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: ()   Date: (2008-6-19)   Pages: ()
  • Author:  M Tsagareli  

  • Abstract:  It was demonstrated that systemic injections of metamizol and lysine-acetylsalicyl ate (LASA) induce inhibition of tail-flick reflex and hot-plate responses and their repeated administration leads to the development of tolerance. However, it has not been established whether these effects can be elicited by other non-steroidal anti-inflammatory drugs (NSAIDs). In this study the authors used other commonly applied analgesics--analgine , ketorolac, xefocam, which are the representatives of the three diverse groups of NSAIDs. In particular, analgine is a derivative of pirozolon, while ketorolac belongs to indoles and xefocam to amoxicams. The authors decided to examine and compare tolerance to analgine, ketorolac and xefocam in groups of young and adult rats. The experiments were carried out on experimental and control rats with saline by the model of tail-flick reflex to the stimulation of focusing light. Latency increase of this reflex indicates the degree of antinociception. The present study has revealed that systemic, intraperitoneal injections of NSAIDs (analgine, ketorolac and xefocam), the equivalent to maximal analgesic doses for humans, induces antinociception in awake rats of young and adult ages and when administered repeatedly, induce tolerance to these drugs and cross-tolerance to morphine. This is in line with results of earlier experiments, in which metamizol or LASA were given intravenously or microinjected into the periaqueductal gray matter. More importantly, the study indicate that the repeated administration of these non-opioid analgesics induces a decrease in antinociceptive effectiveness reminiscent of that induced by opiates. Moreover, the present results paradoxically suggest that analgine, ketorolac and xefocam tolerance is related to the endogenous opioid system. Taken together the present and previous findings the authors support the notion that the contribution of the CNS, particularly of the downstream pain-control system, to the tolerance effects of NSAIDs involve endogenous opioidergic mechanisms.

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

             Answers

             News

               Related on Youtube Results
        • BIBLE STUDY 4/15/2014
          BIBLE STUDY 4/15/2014 Discussing verses from the Holy Bible. From: Benjamin Abellera Views: 0 0 ratings Time: 03:50 More in Nonprofits & Activism
        • Case study presentation: DLBCL stage lVB, IPI 4/5
          Case study presentation: DLBCL stage lVB, IPI 4/5 Prof. Marek Trněný discusses the case of a young male patient with DLBCL, stage lVB considered to be at high risk with an IPI of 4 out 5, and 3 out of 3 aaIPI. Prof. Trněný has published... From: Lymphoma Hub Views: 0 0 ratings Time: 12:39 More in Education
        • Adventures In Learning Japanese Japanese Study Aids Vlog #2
          Adventures In Learning Japanese Japanese Study Aids Vlog #2 From: bunaderakus Views: 0 0 ratings Time: 07:03 More in People & Blogs
        • SysQue Case Study by Mortenson and dbHMS
          SysQue Case Study by Mortenson and dbHMS Jennifer Suerth with Mortenson and Maxwell Nichols with dbHMS speak at the 2014 TSI User Group Meeting about their experiences with SysQue on projects going to permit. From: TechnicalSalesInt Views: 26 0 ratings Time: 49:20 More in Science & Technology
        • BBU Study tour to Koh Kchang by Vytas Cambodia
          BBU Study tour to Koh Kchang by Vytas Cambodia From: Bunsung Heng Views: 2 0 ratings Time: 01:08 More in Travel & Events
        • Why do you study in Japan You は何しに日本へ
          Why do you study in Japan You は何しに日本へ From: bunaderakus Views: 0 0 ratings Time: 02:53 More in People & Blogs
        • BIBLE STUDY 7/22/2014
          BIBLE STUDY 7/22/2014 Discussing verses from the Holy Bible. From: Benjamin Abellera Views: 0 0 ratings Time: 13:54 More in Nonprofits & Activism
        • Study with the University of London from Trinidad and Tobago
          Study with the University of London from Trinidad and Tobago The University of London International Programmes enables you to study for a prestigious University of London qualification without leaving Trinidad. We offer degree programmes developed by... From: University of London International Programmes Views: 0 0 ratings Time: 00:41 More in Education
        • BIBLE STUDY 7/22/2014
          BIBLE STUDY 7/22/2014 Discussing verses from the Holy Bible. From: Benjamin Abellera Views: 0 0 ratings Time: 11:41 More in Nonprofits & Activism
        • BBU Study tour to Koh Kchang by Vytas Cambodia Travel
          BBU Study tour to Koh Kchang by Vytas Cambodia Travel From: Bunsung Heng Views: 2 0 ratings Time: 01:29 More in Travel & Events
        • Bible Study on Revelation Chapter 2 7-22-2014
          Bible Study on Revelation Chapter 2 7-22-2014 We are studying revelation we are in chapter 2. From: Charles Brock Views: 0 0 ratings Time: 44:14 More in People & Blogs
        • Mayo Clinic Study on Caffeine and Menopause
          Mayo Clinic Study on Caffeine and Menopause Dr. Stephanie Faubion discusses a Mayo Clinic study, published by the journal Menopause, which found an association between caffeine intake and more bothersome hot flashes and night sweats... From: Mayo Clinic Views: 4 0 ratings Time: 03:53 More in Science & Technology
        • Endgame Study #197
          Endgame Study #197 An endgame study from the Chess.com Tactics Trainer 8/4p1K1/p7/2P3p1/N1k4p/P3P3/1P2n3/8 w - - 0 1. From: Greg Shahade Views: 3 0 ratings Time: 03:00 More in Gaming
        • BBU Study tour to Koh Kchang by Vytas Cambodia Travel
          BBU Study tour to Koh Kchang by Vytas Cambodia Travel Travel with Vytas Cambodia. From: Bunsung Heng Views: 1 0 ratings Time: 04:42 More in Travel & Events
        • Biblical Study of Creation Part 4
          Biblical Study of Creation Part 4 Richard Stepanek Alpha Omega Institute http://www.discovercreation.org. From: Grace Gospel Views: 0 0 ratings Time: 01:34:51 More in People & Blogs
        • Study Abroad in Spain
          Study Abroad in Spain From: hanovercollege Views: 0 0 ratings Time: 01:20 More in Education
        • JW Study Aid: How to Change the Home Page Language
          JW Study Aid: How to Change the Home Page Language JW Study Aid: How to Change the Home Page Language. From: JW Study Aid Views: 1 0 ratings Time: 01:01 More in Howto & Style
        • Seagull Study: Toronto Summertime Mimico By The Lake= Afternoon 2014 06 10
          Seagull Study: Toronto Summertime Mimico By The Lake= Afternoon 2014 06 10 Seagull Study: Interesting to stop and study this seagull hanging out along the boardwalk of Toronto's Mimico By The Lake. A Summertime Afternoon (2014 06 10). From: Mark Mueller Views: 0 0 ratings Time: 02:10 More in Travel & Events
        • Connie Talbot Wake Me Up Angelo's Edit Pre-Remix Study 7A21
          Connie Talbot Wake Me Up Angelo's Edit Pre-Remix Study 7A21 Connie Talbot Wake Me Up Angelo Edit Pre-Remix Study 7A21 song: c Avicii VEVO ......... ******* July 23, 2014 ******* ........ Youtube 2014..Soft Concert Grand Piano and vocal study mix ... From: LINNLchan7BAND Views: 1 0 ratings Time: 04:27 More in Education
        • sexy girl body dancing study dances 1024104
          sexy girl body dancing study dances 1024104 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 03:17 More in Entertainment
        • sexy girl body dancing study dances 104545605
          sexy girl body dancing study dances 104545605 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 01:45 More in Entertainment
        • sexy girl body dancing study dances 440740100
          sexy girl body dancing study dances 440740100 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 01:53 More in Entertainment
        • sexy girl body dancing study dances 045705412
          sexy girl body dancing study dances 045705412 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 03:07 More in Entertainment
        • sexy girl body dancing study dances 1025045
          sexy girl body dancing study dances 1025045 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 01:40 More in Entertainment
        • sexy girl body dancing study dances 2104021
          sexy girl body dancing study dances 2104021 After a noisy start to the year with many controversies arising due to strong sexual concepts for the many girl groups that returned in January and February, the Korean Communications Standards... From: sexy girl dance Views: 0 0 ratings Time: 03:11 More in Entertainment

        •      Related on Wikipedia




























           

          Powered free by PHPmotion