Study of non-opioid analgesics tolerance in young and adult rats.


     Related Videos
Study in Europe
  • Study in Europe

  • www.study-in-europe.org Europe is a fascinating place to study. But which country should you go to? ...

Study in Europe
  • Study in Europe

  • www.study-in-europe.org Europe is a fascinating place to study. But which country should you go to? ...

So you want to study at Edinburgh?
Somali Y chromosome study
Use of the Kinesiograph in the Study of Jaw Movements

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: ()   Date: (2008-6-19)   Pages: ()
  • Author:  M Tsagareli  

  • Abstract:  It was demonstrated that systemic injections of metamizol and lysine-acetylsalicyl ate (LASA) induce inhibition of tail-flick reflex and hot-plate responses and their repeated administration leads to the development of tolerance. However, it has not been established whether these effects can be elicited by other non-steroidal anti-inflammatory drugs (NSAIDs). In this study the authors used other commonly applied analgesics--analgine , ketorolac, xefocam, which are the representatives of the three diverse groups of NSAIDs. In particular, analgine is a derivative of pirozolon, while ketorolac belongs to indoles and xefocam to amoxicams. The authors decided to examine and compare tolerance to analgine, ketorolac and xefocam in groups of young and adult rats. The experiments were carried out on experimental and control rats with saline by the model of tail-flick reflex to the stimulation of focusing light. Latency increase of this reflex indicates the degree of antinociception. The present study has revealed that systemic, intraperitoneal injections of NSAIDs (analgine, ketorolac and xefocam), the equivalent to maximal analgesic doses for humans, induces antinociception in awake rats of young and adult ages and when administered repeatedly, induce tolerance to these drugs and cross-tolerance to morphine. This is in line with results of earlier experiments, in which metamizol or LASA were given intravenously or microinjected into the periaqueductal gray matter. More importantly, the study indicate that the repeated administration of these non-opioid analgesics induces a decrease in antinociceptive effectiveness reminiscent of that induced by opiates. Moreover, the present results paradoxically suggest that analgine, ketorolac and xefocam tolerance is related to the endogenous opioid system. Taken together the present and previous findings the authors support the notion that the contribution of the CNS, particularly of the downstream pain-control system, to the tolerance effects of NSAIDs involve endogenous opioidergic mechanisms.

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

               Answers

               News

                 Related on Youtube Results
          • Chat with SIT Study Abroad Alumni
            Chat with SIT Study Abroad Alumni Get a change to chat with an alum of Tunisia: Emerging Identities in North Africa. From: SITStudentsandAlumni Views: 0 0 ratings Time: 00:00 More in Entertainment
          • Frédéric Chopin - Study Op. 10 No. 1
            Frédéric Chopin - Study Op. 10 No. 1 Charles Jann's recital in Neuchâtel, Switzerland. From: Jann53976 Views: 0 0 ratings Time: 02:09 More in Music
          • Zen Music concentrate, study, meditation
            Zen Music concentrate, study, meditation Music to concentrate, to study to, for meditation and much more... Zen Garden and Zen - preface: Not only Steve Jobs learned to calm his mind through Zen practice. Mindfulness and reflection... From: Relax Everyday Views: 0 0 ratings Time: 09:03 More in Music
          • Study music relaxing background music
            Study music relaxing background music A ten minute instrumental tested and approved as music for studying, reading, or doing creative mental work. It should also work quite well for meditation and yoga like exersises because of... From: Relax Everyday Views: 0 0 ratings Time: 09:47 More in Music
          • High Rise Study - 3 vs. 4 Crew Size
            High Rise Study - 3 vs. 4 Crew Size From: IAFF Views: 0 0 ratings Time: 15:12 More in News & Politics
          • Residential Fireground Study 3 vs 2 Crew Size
            Residential Fireground Study 3 vs 2 Crew Size From: IAFF Views: 0 0 ratings Time: 14:00 More in News & Politics
          • Residential Fireground Study 4 vs 3 Crew Size
            Residential Fireground Study 4 vs 3 Crew Size From: IAFF Views: 0 0 ratings Time: 14:45 More in News & Politics
          • EMS Deployment Study
            EMS Deployment Study From: IAFF Views: 0 0 ratings Time: 17:58 More in News & Politics
          • High Rise Study - 4 vs. 5 Crew Size
            High Rise Study - 4 vs. 5 Crew Size From: IAFF Views: 0 0 ratings Time: 14:59 More in News & Politics
          • Bible Study: Sin part 1- introduction
            Bible Study: Sin part 1- introduction Bible Study: Sin part 1- introduction. From: Miguel Fuentes Views: 0 0 ratings Time: 01:13:07 More in Entertainment
          • Relaxing Piano Music work, study, meditation
            Relaxing Piano Music work, study, meditation Another soothing, cinematic background music instrumental by relaxdaily. This relaxing piano music can be your perfect soundtrack when you like calm and peaceful music while you work, study,... From: Relax Everyday Views: 0 0 ratings Time: 11:37 More in Music
          • All Video Clips University of Florida Roundabout Study
            All Video Clips University of Florida Roundabout Study Here is a collection of video clips of traffic and pedestrian activity near roundabouts from around Florida as part of an operational/safety study done by the University of Florida in 2013/2014. From: Gary Sokolow Views: 0 0 ratings Time: 05:03 More in Science & Technology
          • GEOTHERMAL TRIP RESOURCE STUDY
            GEOTHERMAL TRIP RESOURCE STUDY Geothermal Tourism Program. From: Kiagus Ridwan Views: 0 1 ratings Time: 03:49 More in Education
          • Plan B Advertising Case Study: TITLE Boxing Club
            Plan B Advertising Case Study: TITLE Boxing Club A case study from Chicago-based advertising agency, Plan B [The Agency Alternative], highlights the brand development, positioning and marketing campaign for one of the fastest growing fitness-base... From: Plan B [the agency alternative] Views: 1 0 ratings Time: 02:51 More in Film & Animation
          • Study Confirms That Reading Harry Potter Will Make You A Better Person
            Study Confirms That Reading Harry Potter Will Make You A Better Person When a long-term relationships end, we describe ourselves as being heartbroken. But can you actually die from a broken heart? Laci and Anthony are here to di. Some people have asked questions,... From: Cristina Lamp Views: 0 0 ratings Time: 00:26 More in People & Blogs
          • New Study Suggests Potential Link Between Birth Control Pills and Cancer - LoneWolf Sager
            New Study Suggests Potential Link Between Birth Control Pills and Cancer - LoneWolf Sager Some types of pills may be associated with an increased risk of breast cancer. - LoneWolf & The Three Muskadoggies. From: LoneWolf Sager Views: 0 0 ratings Time: 01:30 More in News & Politics
          • Bible Study with Uncle J Episode: persecution
            Bible Study with Uncle J Episode: persecution playlist: https://www.youtube.com/playlist?list=PLDC9F7DAE2AE89A4D. From: Josephsyoutification Views: 1 1 ratings Time: 03:54 More in Entertainment
          • Why did NASA fund a study about collapse of the world and then deny any involvement in it?
            Why did NASA fund a study about collapse of the world and then deny any involvement in it? Why is NASA funding a study about the collapse of the world, and then denying they had involvement in the study? If a body or group funds a study, it's usually because they are interested in... From: C. Ervana Views: 0 0 ratings Time: 08:07 More in People & Blogs
          • DDI Case Study – I-15 & SR92/Timpanogos Hwy in Lehi (Utah)
            DDI Case Study – I-15 & SR92/Timpanogos Hwy in Lehi (Utah) This narrated case study explains why the Utah Department of Transportation reconstructed the Interstate 15 and SR92/Timpanogos Highway interchange in the city of Lehi as a Diverging Diamond... From: USDOTFHWA Views: 2 0 ratings Time: 03:12 More in Travel & Events
          • Energize UK Ltd - Installer Case Study
            Energize UK Ltd - Installer Case Study From: DaikinUK Views: 0 0 ratings Time: 02:43 More in Science & Technology
          • GANDIKOTA BUSINESS SCHOOL T NEWS STUDY GUIDE
            GANDIKOTA BUSINESS SCHOOL T NEWS STUDY GUIDE LIVE INTERVIEW WITH GBS CHAIRMAN IN T NEWS STUDY GUIDE PROGRAM ON 31-07-2014. From: Krishna Mohan Chowdary Anne Views: 0 0 ratings Time: 28:35 More in People & Blogs
          • Mr and Mrs Baker - Homeowner Case Study
            Mr and Mrs Baker - Homeowner Case Study From: DaikinUK Views: 1 0 ratings Time: 03:00 More in Science & Technology
          • Does The German Binary Options Robot Work---Case study
            Does The German Binary Options Robot Work---Case study Download Here: http://tiny.cc/4s8vjx Download Here: http://tiny.cc/4s8vjx Download Here: http://tiny.cc/4s8vjx Download from here: http://tiny.cc/4s8vjx Download from here: http://tiny.cc/4s8vjx... From: Doermer Katina Views: 301 0 ratings Time: 03:33 More in Gaming
          • Funny Study Premature 2014 Funny Videos HQ
            Funny Study Premature 2014 Funny Videos HQ Premature 2014 Funny Videos -- HQ ,premature short film on hbo, ,watch premature short film ,premature videos ,premature black hair media ,premature premier ,premature independent ,premature... From: small airo Views: 1 0 ratings Time: 02:32 More in People & Blogs
          • Udder and teat hygiene dairy cow case study
            Udder and teat hygiene dairy cow case study http://canagri.pl/en/guide/3.html This udder and teat hygiene video shows details of a whitepaper you can download at canagri.pl. It covers important issues relating to the care and treatment... From: Molecule Marketing Views: 0 0 ratings Time: 00:44 More in Pets & Animals

          •      Related on Wikipedia




























               

              Powered free by PHPmotion