Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1


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    • Author:  Kawaguchi Y  Miyazawa T  Horimoto T  Itagaki S  Fukasawa M  Takahashi E  Mikami T.  

    • Abstract:  Activation of feline immunodeficiency virus long terminal repeat by feline herpesvirus type 1. Kawaguchi Y, Miyazawa T, Horimoto T, Itagaki S, Fukasawa M, Takahashi E, Mikami T. Department of Veterinary Microbiology, Faculty of Agriculture, University of Tokyo, Japan. By transfection of a recombinant plasmid containing the feline immunodeficiency virus (FIV) long terminal repeat (LTR) linked to the chloramphenicol acetyltransferase (CAT) gene followed by infection of feline herpesvirus type 1 (FHV-1) into Crandell feline kidney cells and Felis catus whole fetus 4 cells, enhancement of CAT activity was demonstrated. Furthermore, individual feline T-lymphocytes were productively co-infected with both FIV and FHV-1 in vitro as determined by two-color immunofluorescence and electron microscopy analyses. These results revealed the transactivation of the FIV LTR by FHV-1 and the dual infection of T-lymphocytes with both viruses. The possibility that FHV-1 might be a cofactor which plays a role in the pathogenesis of FIV infection is discussed. PMID: 1651603 [PubMed - indexed for MEDLINE]

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