Increased virulence of modified-live infectious laryngotracheitis vaccine virus following bird-to-bird passage
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PubMed
(0) (0 Votes)Views: (1056) Date: (27-01-09) Pages: () -
Author: Guy JS Barnes HJ Smith L.
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Abstract: Increased virulence of modified-live infectious laryngotracheitis vaccine virus following bird-to-bird passage. Guy JS, Barnes HJ, Smith L. Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606. Modified-liv e (ML) infectious laryngotracheitis (ILT) vaccine viruses, both tissue-culture-origi n (TCO) and chicken-embryo-origi n (CEO), were passaged 20 times in specific-pathogen-fr ee chickens. After serial bird-to-bird passage, increased virulence was observed for CEO virus but not TCO virus. Increased mortality and increased severity and duration of respiratory disease were observed in chickens inoculated with chicken-passaged CEO viruses; only mild respiratory disease (no mortality) occurred in chickens inoculated with chicken-passaged TCO viruses. These findings suggest that ML ILT vaccine viruses may increase in virulence after bird-to-bird passage. PMID: 1649591 [PubMed - indexed for MEDLINE]
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