Testosterone-induced diminution of two peptides in spleen cells from testosterone-immunosuppressed B10 mice
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PubMed
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Author: Fiebig S Schmitt-Wrede HP Wunderlich F Stangier J Schiltz E.
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Abstract: Testosterone-induced diminution of two peptides in spleen cells from testosterone-immunos uppressed B10 mice. Fiebig S, Schmitt-Wrede HP, Wunderlich F, Stangier J, Schiltz E. Division of Parasitology, Heinrich-Heine-Unive rsity, Dusseldorf, Germany. High-perfo rmance liquid chromatography (HPLC) is used to detect testosterone (T)-sensitive peptides in spleen cells isolated from female C57BL/10 mice immunosuppressed against Plasmodium chabaudi malaria by T treatment. Two peaks with retention times of about 25 min and 34 min, respectively, were identified to be diminished by about 52% and 47%, respectively, in spleen cells from T-treated mice compared to those from untreated mice. Amino acid sequencing revealed that the 24 min peak consisted of the dipeptide Met-Phe and the 34 min peak contained a degradative fragment of the alpha-chain of hemoglobin. Our data suggest that the immunosuppressive T treatment of B10 mice induces a perturbation of erythrophagocytosis in spleens. PMID: 1639211 [PubMed - indexed for MEDLINE]
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