The Roseto effect a 50-year comparison of mortality rates

Roseto is a borough in Northampton County, Pennsylvania, Uni...

Roseto Basket also known as Roseto Sharks and Pallacanestro ...

Some protozoans, such as Trichomonad species, do not possess mitochondria. Most of the time, they harbor another type of membrane-bounded organelle, called hydrogenosome from its capacity to produce H(2). This is the case for the human parasite Trichomonas vaginalis. Some other parasites, such as the protist Giardia lamblia, do not harbor any of these organelles. From this observation arises naturally a naive question: How do cells die when the mitochondrion, the cornerstone of apoptotic process, is absent? Data strongly suggest that the mitoch...

BACKGROUND: The significant and constant progress of biotechnologies applied to sterility and infertility has induced a deeper reflection about bioethical problems. The analysis of only the biological dimension, about the results achieved and desirable future prospects, decreases, leaving out the anthropological dimension. It is therefore necessary to make reference to both the limits of the basic or applied research and to the usual welfare procedure. The aim, that the article sets itself, is to proceed to the bioethical analysis of the most s...

Breast cancer is the most frequent cancer among women in western countries, where it represents about one third of tumors. Many laboratories utilized monoclonal antibodies technology for studying this pathology and for clinical applications. Different immunisation strategies have been utilized in the aim to produce monoclonal antibodies specific of mammary epithelial cells, of cancer cells or of cell secretions products. Despite efforts none of these are entirely specific, either for the normal tissue or for malignant tumors derived from it. Ho...

Two mouse hybridomas, producing the monoclonal antibodies 7B10 and 1BE12 which react with membrane antigens of a metastatic human breast tumor cell line were selected. One of them, 7B10, is directed against a mammary gland antigenic determinant and selectively stain mammary carcinoma on histologic sections after fixation and paraffin embedding.

Predictors of myocardial infarction with or without survival were sought in a 30-year study of Roseto, Pennsylvania, a nearly exclusively Italian community of approximately 1,600, compared to the immediately adjacent town of Bangor with a population of approximately 5,000. At the start of the study the death rate from myocardial infarction among men in Roseto was less than half that in Bangor despite an equal prevalence of the usual risk factors, mainly smoking and diet. The communities were followed prospectively for 30 years during a striking...

In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic neutralizing effect on HIV infection. However, sCD4 and an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.

The findings of a community study of coronary artery disease were reviewed retrospectively to highlight applications to current research and clinical practice. Roseto, Pennsylvania, an ethnically homogenous county, was studied in the 1960s by an interdisciplinary team of researchers. Twenty years later the findings are being confirmed in the studies of other investigators. The major finding was the importance of social support and close family ties in buffering the deleterious effects of stress and life change, factors which have been implicate...

In order to generate an immune response against myeloma cells in an homogenous murine model, a stable hybrid cell line (DCSp) was established through the syngenic fusion between mouse dendritic cells (DC) and mouse Sp2/0 myeloma cells. DCSp cells behaved as potent T cell stimulators and were able to induce Sp2/0 specific cytotoxicity. When mice were immunized with irradiated hybrids before SP2/0 injection, they exhibited a significantly higher rate of survival as compared with controls. When tumors were detected, their emergence was not delayed...

A murine hybridoma, secreting monoclonal antibody ED8, was generated by immunization with the breast cancer cell line H466B. ED8 reacts with a 300 kDa antigen present on H466B cell surface. The antigen can be detected in serum from breast cancer patients, using ELISA and immunoblotting.