Timolol in lipospheres
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PubMed
(0) (0 Votes)Views: (1010) Date: (27-01-09) Pages: () -
Author: Gasco MR Cavalli R Carlotti ME.
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Abstract: Timolol in lipospheres. Gasco MR, Cavalli R, Carlotti ME. Dipartimento di Scienza e Tecnologia, Farmaco Universit? di Torino, Italy. Lipospheres carrying timolol (1) were obtained from microemulsions. They had lecithin, palmitic and decanoic acids as the main constituents. The sizes were between 300 and 400 nm and the amount of 1 incorporated varied from 2.7 to 4.8% according to the microemulsion used. Compound 1 was present in the lipospheres mainly as ion pairs in order to increase its lipophilicity. The difference found in the incorporation was principally due to the different lipophilicity of the ion pairs of 1. PMID: 1635918 [PubMed - indexed for MEDLINE]
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