A case of carcinosarcoma of the lung

Author:  [Article in Japanese]

Abstract:  [A case of carcinosarcoma of the lung] [Article in Japanese] Imaiz umi K, Mizoguchi K, Murate T, Murase K. Department of Respiratory Medicine, Meitetsu Hospital, Nagoya, Japan. A 78-year-old man was admitted to our hospital with cough and left anterior chest pain. Chest X-ray examination on admission revealed a tumor shadow in the left upper lobe. Malignant tumor cells were observed on histopathological examination of a specimen obtained by bronchoscopic biopsy. Radiotherapy was performed but was not effective, and the patient died of respiratory failure 4 months after admission. Autopsy revealed a 15 cm diameter tumor with marked local invasion tendency without distant metastasis. Microscopically, the tumor consisted partly of squamous cell carcinomas, and partly of fibrosarcomas, composed of spindle cells and osteo-chondrosarcoma . The tumor was therefore diagnosed as carcinosarcoma. Immunohistochemical examination showed positive keratin and EMA staining only in the squamous cell carcinoma component of the tumor. PMID: 1625391 [PubMed - indexed for MEDLINE]