Buspirone induced prolactin responses in obsessive-compulsive disorder OCD is OCD a 5-HT2 receptor disorder
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PubMed
(0) (0 Votes)Views: (1028) Date: (27-01-09) Pages: () -
Author: Lucey JV Butcher G Clare AW Dinan TG.
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Abstract: Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? Lucey JV, Butcher G, Clare AW, Dinan TG. Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Eire. Buspirone (BUSP) is a serotonergic (5-HT) agonist with activity at the 5-HT1A receptor. The BUSP induced prolactin (PRL) response was examined in 10 patients with a DSM IIIR diagnosis of obsessive-compulsive disorder (OCD). The results were compared with PRL responses to BUSP found in 10 age and sex matched healthy controls. The results suggest that the 5-HT1A receptor dysfunction may not be involved in the pathophysiology of OCD. The authors review the literature and consider the hypothesis that in OCD a complex interaction of other 5-HT receptor sub-types may be occurring, possibly with dysfunction primarily of the 5-HT2 receptors. PMID: 1624756 [PubMed - indexed for MEDLINE]
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