Immunologic phenotype of lymphocytes in chronic B-cell lymphocytic leukemia II Studies of immunologic phenotype of peripheral blood and lymph node lymphocytes in patients with chronic lymphocytic leu...

Abstract:  [Immunologic phenotype of lymphocytes in chronic B-cell lymphocytic leukemia. II. Studies of immunologic phenotype of peripheral blood and lymph node lymphocytes in patients with chronic lymphocytic leukemia or leukemic forms of lymphoplasmacytoid lymphoma] [Article in Polish] Rupniew ska ZM, Rozynkowa D, Antosz H, Kowal M, Wach M, Rolinski J. Kliniki Hematologii AM, Lublinie. In a group of 16 patients with chronic lymphocytic leukaemia and leukaemic forms of the lymphoma lymphoplasmocytoides immunophenotypes of peripheral blood and lymph node lymphocytes were studied. Conclusions: 1) immunophenotype heterogeneity observed in a minority of patients in lymph-nodes or peripheral blood seems to be connected with the co-existence of leukaemic and normal reactive B-cells, 2) SIgG+ cells seem to represent activated B lymphocytes producing and secreting autoantibodies, 3) circulating peripheral T lymphocytes do not reflect the distribution of T cell subpopulations in lymph-nodes. PMID: 1615749 [PubMed - indexed for MEDLINE]