Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice.


     Related Videos
Vitiligo Treatment and by herbal Medicin
The Promise and Perils of Herbal Remedies
herbal male enhancement treatment in india
Intro to Asian Medicine Chinese Herbal Qigong Tui Na
Pure Garcinia Cambogia Extract

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: ()   Date: (2009-12-16)   Pages: ()
  • Author:  Pei-Wen Hsiao  

  • Abstract:  PURPOSE: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer. EXPERIMENTAL DESIGN: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft. RESULTS: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)-positive prostate cancer cells and shifted the proportion in each phase of cell cycle toward G(2)-M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively) sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo. CONCLUSION: Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis. Future studies of W. chinensis for chemoprevention or complementary medicine against prostate cancer in humans are thus warranted.

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

               Answers

                 News
            • Herbal medicines could contain dangerous levels of toxic mold
              ( Elsevier ) Herbal medicines such as licorice, Indian rennet and opium poppy, are at risk of contamination with toxic mold, according to a new study published in Fungal Biology. The authors of the study, from the University of Peshawar, Pakistan say it's time for regulators to control mold contamination.
            • Asia Herbal expands operations to Indonesia
              KUALA LUMPUR: Asia Herbal Biotech Sdn Bhd (AHB) has expanded its operation overseas with the opening of its first office, PT Asia Herbal Biotech, in Jakarta. For a start, the manufacturer of cordyceps-based healthcare products has appointed 2,000 agents to market three products in the country, namely coffee drinks, Cordydaylite and Cordyvitaplus. AHB executive chairman Tan Sri Dr Jason Goh said ...
            • Tronex Herbal Solutions presents 2013-2014 Nong’s Scholarship to Chien Liang Lin at the New York College of ...
              Tronex Herbal Solutions is proud to present the 2013-2014 Nong’s Scholarship to Chien Liang Lin at the New York College of Traditional Chinese Medicine . Tronex Herbal is honored to recognize excellence in education at the New York College of Traditional Chinese Medicine. (PRWeb October 20, 2014) Read the full story at http://www.prweb.com/releases/2014/10/prweb12254495.htm
            • Affinor Growers Announces Licensing LOI with Herbal Clone Bank Canada Inc.
              Affinor Growers Affinor" or the "Corporation) announces that Herbal Clone Bank Canada Inc. have entered into a letter of intent to license a new designed automated vertical cloning machine technology......
            • Summit County marijuana shops react to proposed limits on edibles
              Herbal Bliss, a marijuana dispensary in Frisco, sells pot-infused hard candies with strawberry kiwi flavoring inside a childproof container.
            • Herbal medicine maker Ouay Un Osoth eyes Asean
              Ouay Un Osoth, a manufacturer of herbal medicines and supplements for more than 67 years, has set aside a marketing budget of Bt10 million to rebrand and launch new herbal products during the remaining months of the year.
            • Ministry to launch herbal development division
              KUALA LUMPUR: The Agriculture and Agro-based Industries Ministry is set to launch the Herbal Development Division under its wing to expand the Malaysian herbal market. Its minister  Datuk Seri Ismail Sabri Yaakob said the potential for the nation’s herbal industry was great and the establishment of the special division would help promote and develop the industry. “The global herbal market is ...
            • Govt cut VAT on herbal tea
              The Government is cutting the VAT rate on herbal tea as part of measures included in the Finance Bill.
            • Tronex Herbal Solutions Supplement Oncozac® ONCO-Z Earns United States Pharmacopeia (USP) Verified Dietary Ingredient
              Tronex Herbal Solutions supplement Oncozac® ONCO-Z (Coriolus Versicolor or Yun zhi) earns USP verified dietary ingredient. Available in capsule form, Yun zhi has been shown to improve survival rates , ease symptoms and boost the immune system of patients receiving radiation therapy, chemotherapy and surgery for various cancers, including breast cancer.* (PRWeb October 14, 2014) Read the full ...
            • Herbal incense illegal
              The sale or possession of herbal incense — “synthetic cannabinoids” available locally that go by the names “K2,” “Voodoo,” “FIYA” and “Spice” — became illegal today.

                 Related on Youtube Results
          • usaha, SEMUT HERBAL SEMUT,OBAT, SEMUT BERKHASIAT, SEMUT JEPANG,
            usaha, SEMUT HERBAL SEMUT,OBAT, SEMUT BERKHASIAT, SEMUT JEPANG, usaha, SEMUT HERBAL SEMUT,OBAT, SEMUT BERKHASIAT, SEMUT JEPANG, Hubungi : 085713157686 https://www.facebook.com/manfaatkhasiatJualsemutJepang SEMUT JEPANG SEMUT ... From: Mitoni Satinah Views: 0 0 ratings Time: 00:07 More in Entertainment
          • Cara Membuat Jamu Temulawak Resep Herbal
            Cara Membuat Jamu Temulawak Resep Herbal sinetron, ftv, film, movie, drama, cinta, sctv, indosiar, film drama, movie drama, film tv, episode, full movie, full, hidayah, ftv hidayah, indosiar, sctv, terbaru, 2014, terbaru 2014. From: teratv Views: 0 0 ratings Time: 01:28 More in Film & Animation
          • Kad Jimat Tenaga Neu Herbal
            Kad Jimat Tenaga Neu Herbal Keterangan lanjut hubungi 017-7196959. From: ULike UShare Views: 0 0 ratings Time: 00:24 More in People & Blogs
          • obat herbal kanker kelenjar getah bening
            obat herbal kanker kelenjar getah bening obat herbal kanker kelenjar getah bening sokusi cara mengobati kanker kelenjar getah bening tanpa operasi ... From: obat kelenjar getah bening Views: 0 0 ratings Time: 00:52 More in People & Blogs
          • Natural herbal
            Natural herbal Pleas call me? From: Natural Herbal Views: 2 0 ratings Time: 02:24 More in Entertainment
          • Mast Mood Male Enhancement Herbal Oil For Strong Erection In Men
            Mast Mood Male Enhancement Herbal Oil For Strong Erection In Men This video describes about Mast Mood male enhancement herbal oil for strong erection in men. You can find more detail about Mast Mood oil at http://www.dharmanis.com. From: Abram Wilson Views: 0 0 ratings Time: 03:23 More in People & Blogs
          • How To Increase Penis Strength With The Help Of Herbal Remedies
            How To Increase Penis Strength With The Help Of Herbal Remedies This video describes about how to increase penis strength with the help of herbal remedies. You can find more detail about Overnight oil at http://www.askhomeremedies.com. From: Abram Wilson Views: 0 0 ratings Time: 03:27 More in People & Blogs
          • Best Herbal Treatment For Small Penis Problem, Improves Erection In Men
            Best Herbal Treatment For Small Penis Problem, Improves Erection In Men This video describes about the best herbal treatment for small penis problem, improves erection in men. You can find more detail about Overnight oil and 4T Plus capsules at http://www.ayurvedresear... From: Abram Wilson Views: 0 0 ratings Time: 03:21 More in People & Blogs
          • Herbal Remedies For Urticaria | Herbal Remedies For Hives Urticaria
            Herbal Remedies For Urticaria | Herbal Remedies For Hives Urticaria Visit ▻▻http://urticaria.clic27.com ◅◅ Herbal Remedies For Urticaria | Herbal Remedies For Hives Urticaria Hi my name is Erin Hardy! Welcome to my channel and to this video, today... From: Erin Hardy Views: 0 0 ratings Time: 03:21 More in People & Blogs
          • how to use Snoop Dogg G Pen Herbal e cigarette
            how to use Snoop Dogg G Pen Herbal e cigarette buy Snoop Dogg G Pen Herbal here: http://www.vapingproduct.com/snoop-dogg-g-pen-herbal-double-g-series-p-2.html. From: vapingproduct Views: 1 0 ratings Time: 01:27 More in People & Blogs
          • Nicole Scherzinger Herbal Essences Airplane Commercial Organic Experience
            Nicole Scherzinger Herbal Essences Airplane Commercial Organic Experience I think these commercials are tacky and silly. But that doesn't mean they aren't effective. From: Peter Sattler Views: 0 0 ratings Time: 00:30 More in Film & Animation
          • Lavender Herbal Insect Repellent
            Lavender Herbal Insect Repellent From: Yuh Fun Views: 0 0 ratings Time: 01:23 More in Howto & Style
          • how to use micro G Pro Herbal Vaporizer™ e cigarette by Grenco Science
            how to use micro G Pro Herbal Vaporizer™ e cigarette by Grenco Science Buy micro G Pro Herbal Vaporizer: http://www.vapingproduct.com/g-pro-herbal-vaporizer-by-grenco-science-p-1.html this is a step by step guide for you to use the g pro Herbal Vaporizer™... From: vapingproduct Views: 0 0 ratings Time: 02:05 More in People & Blogs
          • Diabetes Herbal Remedy Here For You-- WOW HEY
            Diabetes Herbal Remedy Here For You-- WOW HEY Diabetes Herbal Remedy Here For You-- WOW HEY http://greatinfo.me/curediabetes I reckon you should have a look at this video to find out how to naturally learn how to beat your diabetes. ... From: Bellas Reviews Views: 0 0 ratings Time: 43:29 More in Entertainment
          • 087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol
            087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol www.sohoherbal.com Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Herbal , Obat Diabetes Kering , Obat Diabetes... From: Pusat Obat Herbal Alami Views: 0 0 ratings Time: 01:27 More in People & Blogs
          • 087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol
            087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol www.sohoherbal.com Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Herbal , Obat Diabetes Kering , Obat Diabetes... From: Pusat Obat Herbal Yogyakarta Views: 0 0 ratings Time: 01:27 More in People & Blogs
          • 087 834 253 255 (XL), Obat Diabetes Herbal, Obat Diabetes Alami Mellitus
            087 834 253 255 (XL), Obat Diabetes Herbal, Obat Diabetes Alami Mellitus www.sohoherbal.com Obat Diabetes Herbal , Obat Diabetes Alami Mellitus, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Kering , Obat Diabetes Basah , Obat Diabetes Melitus Tipe... From: Pusat Obat Herbal Yogyakarta Views: 2 1 ratings Time: 01:28 More in People & Blogs
          • Manfaat herbal/bekam tweet@bekamobat 081809200777
            Manfaat herbal/bekam tweet@bekamobat 081809200777 From: muhammadb yaman Views: 0 0 ratings Time: 00:08 More in People & Blogs
          • 087 834 253 255 (XL), Obat Diabetes Herbal, Obat Diabetes Alami Mellitus
            087 834 253 255 (XL), Obat Diabetes Herbal, Obat Diabetes Alami Mellitus www.sohoherbal.com Obat Diabetes Herbal , Obat Diabetes Alami Mellitus, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Kering , Obat Diabetes Basah , Obat Diabetes Melitus Tipe... From: Pusat Obat Herbal Alami Views: 0 0 ratings Time: 01:28 More in People & Blogs
          • 087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol
            087 834 253 255 (XL), Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol www.sohoherbal.com Obat Diabetes Alami Herbal, Obat Herbal Diabetes Dan Kolesterol, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Herbal , Obat Diabetes Kering , Obat Diabetes... From: Pusat Penjualan Herbal Termurah Views: 6 2 ratings Time: 01:27 More in People & Blogs
          • 087 834 253 255 (XL), obat diabetes herbal, obat diabetes alami mellitus
            087 834 253 255 (XL), obat diabetes herbal, obat diabetes alami mellitus www.sohoherbal.com Obat Diabetes Herbal , Obat Diabetes Alami Mellitus, Obat Diabetes Alami , Obat Diabetes Melitus , Obat Diabetes Kering , Obat Diabetes Basah , Obat Diabetes Melitus Tipe... From: Pusat Penjualan Herbal Termurah Views: 9 2 ratings Time: 01:28 More in People & Blogs
          • Oral Herbal Remedy For Fleas On Cats
            Oral Herbal Remedy For Fleas On Cats From: Mia Varrog Views: 0 0 ratings Time: 01:24 More in Howto & Style
          • Herbal Cleanse Weight Loss Supplement Review
            Herbal Cleanse Weight Loss Supplement Review Have you thought about using the "Herbal Cleanse" supplement? The link below will provide you with more information on this product! http://herbalcleansereview.com/ how to use Herbal Cleanse,... From: Tucker Fox Views: 0 0 ratings Time: 00:27 More in People & Blogs
          • Herbal Magic - Summer Slimdown
            Herbal Magic - Summer Slimdown Produced by Kingstar Direct an award-winning DRTV marketing and production group providing top creative and exceptional production value - visit us at: http://www.kingstar.tv. From: Kingstar Direct Media Views: 0 0 ratings Time: 02:01 More in Film & Animation
          • The New American Herbal by Stephen Orr [PDF]
            The New American Herbal by Stephen Orr [PDF] Download: http://bit.ly/1nz398Z The New American Herbal by Stephen Orr [PDF] "Publisher: Clarkson Potter (September 30, 2014) From modern garden master Stephen Orr comes a new, definitive... From: Debra Squire Views: 0 0 ratings Time: 00:17 More in People & Blogs

          •      Related on Wikipedia




























             

            Powered free by PHPmotion