Chondrogenic differentiation of adult mesenchymal stem cells and embryonic stem cells
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IEEE
(0) (0 Votes)Views: (2015) Date: (Publication Date: 3-5 April 20...) Pages: () -
Author: Shu K. Thatte H. Spector M. Massachusetts Inst. of Technol. Cambridge MA;
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Abstract: Abstract Mesenchyma l stem cell (MSC) contraction associated with chondrogenesis is attributed to the expression of alpha-smooth muscle actin (alpha-SMA). In this study, pluripotent embryonic carcinoma cells (ECCs) and MSCs were compared for cartilage histogensis. Both cell types expressed alpha-SMA in monolayer. However, when cultured in pellets and in 3-D scaffolds, only MSCs contracted and formed glycosaminoglycan (GAG)- and type II collagen-rich tissue. Under these culture conditions, MSCs appear to be superior over ECCs for cartilage regeneration.
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