Association of recombinant soluble IL-6-signal transducer gp130 with a complex of IL 6 and soluble IL-6 receptor and establishment of an ELISA for soluble gp130
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PubMed
(0) (0 Votes)Views: (1018) Date: (20-01-09) Pages: () -
Author: Yasukawa K Futatsugi K Saito T Yawata H Narazaki M Suzuki H Taga T Kishimoto T.
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Abstract: Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130. Yasukawa K, Futatsugi K, Saito T, Yawata H, Narazaki M, Suzuki H, Taga T, Kishimoto T. Biotechnology Research Laboratory, Tosoh Corporation, Kanagawa, Japan. IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic regions was expressed in COS7 cells or CHO cells. sgp130 could associate with a complex of IL-6 and soluble IL-6R (sIL-6R), also lacking transmembrane and cytoplasmic regions. This indicated that extracellular region of gp130 was responsible for the association with IL-6R which was occupied by IL-6. An enzyme-linked immunosorbent assay (ELISA) for the quantitation of sgp130 was established, which was based on the interaction of sgp130 with the complex of IL-6 and sIL-6R and could detect sgp130 as low as 1 ng/ml. PMID: 1740350 [PubMed - indexed for MEDLINE]
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