Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS

Field: Medicine   DOWNLOAD   BOOKMARK  REPORT   

  • PubMed  status
    (0) (0 Votes)
    		Views: (1060)  
    Date:     (20-01-09)  
    Pages:     ()

  • Author:  Diwakar L, Kenchappa RS, Annepu J, Saeed U, Sujanitha R, Ravindranath V.

  • Abstract:Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS. Diwakar L, Kenchappa RS, Annepu J, Saeed U, Sujanitha R, Ravindranath V. Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, 122050, India. beta-N-oxaly l-amino-L-alanine, (L-BOAA), an excitatory amino acid, acts as an agonist of the AMPA subtype of glutamate receptors. It inhibits mitochondrial complex I in motor cortex and lumbosacral cord of male mice through oxidation of critical thiol groups, and glutaredoxin, a thiol disulfide oxido-reductase, helps maintain integrity of complex I. Since incidence of neurolathyrism is less common in women, we examined the mechanisms underlying the gender-related effects. Inhibition of complex I activity by L-BOAA was seen in male but not female mice. Pretreatment of female mice with estrogen receptor antagonist ICI 182,780 or tamoxifen sensitizes them to L-BOAA toxicity, indicating that the neuroprotection is mediated by estrogen receptors. L-BOAA triggers glutathione (GSH) loss in male mice but not in female mice, and only a small but significant increase in oxidized glutathione (GSSG) was seen in females. As a consequence, up-regulation of gamma-glutamyl cysteinyl synthase (the rate-limiting enzyme in glutathione synthesis) was seen only in male mouse CNS but not in females. Both glutathione reductase and glutaredoxin that reduce oxidized glutathione and protein glutathione mixed disulfides, respectively, were constitutively expressed at higher levels in females. Furthermore, glutaredoxin activity in female mice was down-regulated by estrogen antagonist indicating its regulation by estrogen receptor. The higher constitutive expression of glutathione reductase and glutaredoxin could potentially confer neuroprotection to female mice. PMID: 17109834 [PubMed - indexed for MEDLINE]

Write a Comment


     Related Documents
Regulation of gene regulation - smooth binding with dynamic affinity affects evolvability

  • Regulation of gene regulation - smooth binding with dynamic affinity affects evo...

  • Abstract Understanding the evolvability of simple differentiating multicellular systems is a fundamental problem in the biology of genetic regulatory networks and in computational applications inspired by the metaphor of growing and developing networks of cells. We compare the evolvability of a static network model to a more realistic regulatory model with dynamic structure. In the former model, each regulatory protein-binding site is always influenced by exactly one gene product. In the latter model, binding is only more likely to occur the b...

 Regulation of uterine function a biochemical conundrum in the regulation of smooth muscle ...

  • Regulation of uterine function a biochemical conundrum in the regulation of smoo...

  • Regulation of uterine function: a biochemical conundrum in the regulation of smooth muscle relaxation. Buxton IL. Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA. buxton@med.unr.edu Premature birth accounts for the majority of fetal morbidity and mortality in the developed world and is disproportionately represented in some populations, such as African Americans in the United States. The costs associated with prematurity are staggering in both monetary and human terms. Present therapeutic approaches f...

 Down-regulation of CXCR4 expression by tamoxifen is associated with DNA methyltransferase ...
A Refined Regulation Model for Incentive Regulation of Electric Power Transmission and Dis...

  • A Refined Regulation Model for Incentive Regulation of Electric Power Transmissi...

  • Abstract After the reform of the electrical power industry, the vertical integration management control method has been accepted by the electric power transmission and distribution firms in China, where necessary supervision and control are needed. In this paper, the author firstly investigates the existing research studies and the current regulation methods of international electric power market and then proposes a refined regulation model by considering the particularity of the electric power transmission and distribution enterprises in Chin...

 Mathematical Analysis Of The Baroreflex Regulation And Its Interaction With Blood Flow Reg...
Mathematical Analysis Of The Baroreflex Regulation And Its Interaction With Blood Flow Reg...
Anexplanation of the Regulation Failure in the Taxicab Industry - Tested on the Case of th...
Anexplanation of the Regulation Failure in the Taxicab Industry - Tested on the Case of th...
Anexplanation of the Regulation Failure in the Taxicab Industry - Tested on the Case of th...
Repeated SKF 38393 and nigrostriatal system neuronal responsiveness functional down-regula...

  •       > LOGIN OR SIGN UP FOR FREE NOW!




         Related Videos
    Online Gambling Regulation: Lecture Series Event
    Ensuring Accountable Government Regulation: Lessons Learned, Challenges Ahead
    Lec 14 | MIT 7.014 Introductory Biology, Spring 2005
    Jon Hanson: Regulation Reactance - Part 4
    Jon Hanson: Regulation Reactance - Part 2
    Jon Hanson: Regulation Reactance - Part 1
    Jon Hanson: Regulation Reactance - Part 3
    CFA talk 12th June 2009- Stephen Kinsella (part 1)
    Sustainability, climate change and crazy biofuels policy
    1. Finance and Insurance as Powerful Forces in Our Economy and Society

         Related Groups
    EU-Eco-regulation
    Regulation (law)
    Regulation NMS

    • Regulation NMS

    • Regulation NMS (or Reg NMS — Regulation National Market Sy...

     Regulation 17

    • Regulation 17

    • Regulation 17 () was a regulation of the Ontario Ministry of...

     Self-regulation
    Regulation Q

    • Regulation Q

    • Regulation Q is a United States government regulation that p...

     War of the Regulation
    CLP Regulation

    • CLP Regulation

    • The CLP RegulationFull title: Regulation (EC) No 1272/2008 o...

     Regulation D

    • Regulation D

    • In the United States under the Securities Act of 1933, any o...

     Regulation

    • Regulation

    • Regulation is "controlling human or societal behaviour by ru...

         Embed on a Website/Blog
    • URL:




























     

    Powered free by PHPmotion