GroupAdaBoost for selecting important genes

Abstract:  Abstract This paper proposes GroupAdaBoost as a variant of AdaBoost for statistical pattern recognition. The objective of the proposed algorithm is to solve the p ≫ n problem arisen in bioinformatics. Typically, p is the number of investigated genes and n is number of individuals in a microarray experiment for observing gene expressions in a problem to extract any speci c pattern of gene expressions related to a disease status. The ordinary method for predicting the genetic causes of diseases is apt to over-learn from any particular training dataset because of facing p ≫ n problem. We observed that GroupAdaBoost gave a robust performance for cases of the excess number of genes. In several real datasets, which are publicly available from Web-pages, we compared the analysis of results among the proposed method and others, and a small scale of simulation study to confirm the validity of the proposed method.