Chelation in metal intoxication. XXXIV. Mixed ligand chelation in lead poisoning.


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    • Author:  S K Tandon  

    • Abstract:  The effectiveness of alpha-mercapto-beta- (2-furyl)acrylic acid (MFA) and N-benzyl-N-dithiocar boxy-D-glucamine (NaB), used in combination, in the mobilization and excretion of lead was investigated in rats. Male Wistar rats received 10 mg Pb/kg as lead acetate intragastrically daily for 6 weeks. The lead-exposed rats were treated with either MFA or NaB or both 200 mumol/kg i.p., each, daily for 3 days. Both chelating agents provoked significant urinary and faecal excretion and lowered the soft-organ lead burden. However, combined therapy did not elicit any additive or synergistic response.

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