Studies of interactions among cobalt(III) polypyridyl complexes, 6-mercaptopurine and DNA.

Abstract:  The interactions between cobalt polypyridyl coordination compounds Co(L)(3)(3+)(L=1,10- phenanthroline(phen) , and bipyridine(bpy)),6-m ercaptopurine and calf thymus DNA have been investigated using electrochemical methods(cyclic voltammetry, differential pulse voltammetry), electronic absorption spectroscopy and viscosity measurements. Results indicate that there is an obvious interaction equilibrium between Co(L)(3)(3+), 6-mercaptopurine and DNA. The phenomena are investigated for the first time, and believed to be helpful to use the anticancer drugs more efficiently.