Coexistence of IgA antibodies to desmogleins 1 and 3 in pemphigus vulgaris, pemphigus foliaceus and paraneoplastic pemphigus.


     Related Videos

     Related Hubpages

    Field: Medicine  DOWNLOAD  BOOKMARK REPORT
    •  Doc. Url:    Embed Code: 

    • PubMed  status
      (0) (0 Votes)
      		Views: (7)   Date: (2007-2-1)   Pages: ()

    • Author:  H H Pas  

    • Abstract:  BACKGROUND: Pemphigus is a bullous mucocutaneous autoimmune disease characterized by IgG autoantibodies to desmoglein (Dsg) 1 and/or Dsg3. Occasionally direct immunofluorescence of pemphigus skin reveals IgA depositions with an intraepidermal intercellular pattern in addition to the IgG deposition. OBJECTIVES: To investigate if pemphigus patients, in addition to having IgG autoantibodies, also generate IgA antibodies to Dsg1 and/or Dsg3. PATIENTS/METHODS: Sera of 100 pemphigus patients and 36 bullous pemphigoid controls were tested by IgA enzyme-linked immunosorbent assay (ELISA) to the recombinant extracellular domains of Dsg1 and Dsg3. The patients were selected on clinical grounds and positive IgG ELISA index values for Dsg1 and/or Dsg3. They were divided into four groups: patients having IgG to only Dsg1 (n=34), patients having IgG to both Dsg1 and Dsg3 (n=31), patients having IgG to only Dsg3 (n=27) and patients who had paraneoplastic pemphigus (PNP) (n=8). RESULTS: IgA antibodies to Dsg1 were found in 13 (38%) of the patients with IgG to Dsg1, in five (16%) of the patients with IgG to both Dsg1 and Dsg3, in four (15%) of the patients with IgG to Dsg3 and in none of the PNP patients. IgA antibodies to Dsg3 were found in one (3%) of the patients with IgG to Dsg1, in 18 (58%) of the patients with IgG to both Dsg1 and 3, in 18 (67%) of the patients with IgG to Dsg3, and in four (50%) of the PNP patients. Immunofluorescence analysis demonstrated intraepidermal intercellular staining IgA antibodies in serum and intercellular IgA deposits in skin of IgA ELISA-positive patients, although to a lesser extent than by ELISA. CONCLUSIONS: This study shows that in a considerable number of supposedly IgG-mediated pemphigus patients IgA to Dsg1 and Dsg3 is also present. In most cases the antigen specificity of the IgA follows the antigen specificity of the IgG, although in a small number of cases IgA is present against the Dsg not recognized by IgG.

         Related Documents

           Related Groups

             Related Science News

               More on Sciencestage

                 Answers

                 News
            • Science in a Complex World: On the mathematics of biodiversity
              Mathematics might seem like a strange tool to use to describe the biological world. Nature can seem pretty random. It turns out, though, that the plants and animals and bacteria and the other forms of life that surround us display extraordinary mathematical relationships.
            • Racism in Israel
              The Negev Coexistence Forum has some shocking revelations in its alternative report to the UN Committee on the Elimination of Racial Discrimination, in this case in Israel, against the Bedouin population in the Negev-Neqab, to be reviewed on February 15 and 16. The allegations in the report expose Israel's violation of the legally-binding ICERD.
            • Book Review: No, We Can't: Radical Islam, Militant Secularism and the Myth of Coexistence by Robert Stearns
              Can radical Islam, militant secularism and Judeo-Christianity co-exist in a free democratic society? Probably not.
            • Alexander Preps Base For March Republican Primary
              Political gatherings are often places of unlikely coexistence.The 37th annual Lincoln Day Gala of the Shelby County Republican Party included an aucti...
            • Anti-Arab death threats painted on school in Israel
              The school tagged had been a symbol of coexistence. Police in Israel believe Jewish extremists are responsible. read more
            • The Space Station Workspace
              Although it’s obviously not actually in outer space, this gently lit workspace by Flickr user skorpion24 utilises imagery to set the theme. But what makes this setup particularly nice is the arrangement of self-made shelves with plants, books and gadgets in organised coexistence. In addition to the shelves, skorpion24 also made the desk. According to the original post, he’s happy to ...
            • Text of Hariri's speech commemorating father's assasination
              -Hariri reiterates his solidarity with the Syrian people and his will to prevent Sunni-Shiite strife in Lebanon: -All forms of reckless policies will not be able to take Lebanon back to the era of hegemony and domination -Our hands are extended to cooperation with the Syrian National Council, in which we see a hope for Syria
            • The Space Station Workspace [Featured Workspace]
              # featuredworkspace Although it's obviously not actually in outer space, this gently lit workspace by Flickr user skorpion24 utilizes imagery to set the theme. But what makes this setup particularly nice is the arrangement of self-made shelves with plants, books, and gadgets in organized coexistence. In addition to the shelves, skorpion24 also made the desk. According to the original post, he's ...
            • China hopes for stable, healthy ties with the Maldives
              Chinese Foreign Ministry spokesman Liu Weimin said Monday that China hopes to work closely with the Maldives government to develop the two countries' ties in a stable, healthy and smooth way under the Five Principles of Peaceful Coexistence.
            • Rabbi Ammiel Hirsch: Turning Enemies Into Friends In Israel and the Palestinian Territories
              Religious moderates must build new bridges of coexistence or religious extremists will burn the last bridges of peace.

                 Related on Wikipedia




























             

            Powered free by PHPmotion