Discovering DNA: Friedrich Miescher and the early years of nucleic acid research.

     Related Videos
4 Discovering Exoplanets Hot Jupiters
4 Discovering Exoplanets Hot Jupiters
Mark Age - Discovering the secrets of ageing
Greatest Experiments Discovering Oxygen
Discovering the affair - Marion and Geoff - BBC comedy

     Related Hubpages

  •  Doc. Url:    Embed Code: 

  • PubMed  status
    (0) (0 Votes)
    Views: (1)   Date: (2007-9-29)   Pages: ()
  • Author:  Friedrich Miescher  

  • Abstract:  In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of T√ľbingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA. In his experiments, Miescher noticed a precipitate of an unknown substance, which he characterised further. Its properties during the isolation procedure and its resistance to protease digestion indicated that the novel substance was not a protein or lipid. Analyses of its elementary composition revealed that, unlike proteins, it contained large amounts of phosphorous and, as Miescher confirmed later, lacked sulphur. Miescher recognised that he had discovered a novel molecule. Since he had isolated it from the cells' nuclei he named it nuclein, a name preserved in today's designation deoxyribonucleic acid. In subsequent work Miescher showed that nuclein was a characteristic component of all nuclei and hypothesised that it would prove to be inextricably linked to the function of this organelle. He suggested that its abundance in tissues might be related to their physiological status with increases in "nuclear substances" preceding cell division. Miescher even speculated that it might have a role in the transmission of hereditary traits, but subsequently rejected the idea. This article reviews the events and circumstances leading to Miescher's discovery of DNA and places them within their historic context. It also tries to elucidate why it was Miescher who discovered DNA and why his name is not universally associated with this molecule today.

     Related Documents

         Related Groups

           Related Science News

             More on Sciencestage

               Answers

                 News
            • Discovering Dad
              Venice painter and filmmaker Juri Koll on hosting his artist father‚Äôs first gallery show a year after losing him Over the past three decades, Juri Koll has become an institution among the artistic community in Venice. His father ‚ÄĒ San‚Ķ
            • Discovering the Kingdom
               Historical monuments and sites can be found throughout Saudi Arabia. The Kingdom offers several tourist places such as atmospheric souqs and villages reflecting the heritage and culture of Saudi Arabia. This city is glamorous and filled with cultural and modern activities, shopping and cultural sightseeing places. Riyadh is one of the wealthiest cities in the world.
            • Warren Gerds/Critic at Large: Review: ‚ÄėDiscovering Austen‚Äô brings personality to author
              PHOTO: Kristin Hammargren performs in her play, ‚ÄúDiscovering Austen,‚ÄĚ about novelist Jane Austen. Photo courtesy of Grant Griffiths APPLETON , Wis. (WFRV) ‚Äď Jane Austen wrote books a long time ago. That‚Äôs about all I knew before seeing ‚ÄúDiscovering Austen‚ÄĚ Thursday night at Cloak Theatre of Lawrence University. I came away with glimpses and snippets that added up to a frisky foray into theater ...
            • 'Discovering Lucy Angel' Cast & Exec Producer Dish on What to Expect From the Reality Show
              Country music fans will get a inside look at the path to stardom on Jan. 13 with the premiere of Discovering Lucy Angel. The 13-episode series will...
            • Amazing Rotating Hotel in Portugal: Design and Wine
              Discovering new cutting edge hotel properties is always exciting and I found something totally unique in the northern seaside town of Caminha in Portugal where there is an amazing high tech 4 star luxury hotel, the Design & Wine Hotel. The hotel has five suites installed on a raised platform with [...]
            • MacroGenics Announces Closing of Collaboration and License Agreement with Janssen to Develop MGD011 for Multiple B ...
              MacroGenics, Inc. (NASDAQ: MGNX), a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer and autoimmune ...
            • Beer compound could help fend off Alzheimer's and Parkinson's diseases
              The health-promoting perks of wine have attracted the spotlight recently, leaving beer in the shadows. But scientists are discovering new ways in which the latter could be a more healthful beverage than once thought. It turns out that a compound from hops could protect brain cells from damage -- and potentially slow the development of disorders such as Alzheimer's and Parkinson's diseases.
            • Discover The Ultimate Chocolate Experience With New BROOKSIDE Chocolate's Crunchy Clusters
              HERSHEY, Pa., Jan. 27, 2015 /PRNewswire/ -- Brookside Chocolate is the ideal snack for discovering unique flavor combinations, and the latest offering adds an unexpected crunch. Introduced today from The Hershey Company (HSY), Brookside Chocolate's Crunchy Clusters combine crispy multigrains of rice, toasted oats, and graham cracker bits with fruit flavored centers covered in smooth dark ...
            • GW Pharmaceuticals to Report Q1, 2015 Financial Results and Host Conference Call on 4 February, 2015
              LONDON -- GW Pharmaceuticals plc (AIM:GWP) ("GW" or "the Company"), a biopharmaceutical company focused on discovering, developing and commercializing novel therapeutics from its proprietary ...
            • Discovering the wonders of geocaching
              Outdoors columnist Ernie Cowan explains the excitement of high-tech treasure hunting known as geocaching

                 Related on Youtube Results
          • Discovering Fun Family Dinner Ideas and Recipes
            Discovering Fun Family Dinner Ideas and Recipes What was your latest dinnertime discovery? It's a given that Moms will hit a wall and run out of fun dinner ideas for famil. Adell Shneer from The Canadian Living Test Kitchen shows Jane... From: Doretta Shirl Views: 0 0 ratings Time: 06:30 More in Film & Animation
          • John Hagee 2015, 'Discovering the God of the Bible - Recognizing the Truth of God' Conclusion
            John Hagee 2015, 'Discovering the God of the Bible - Recognizing the Truth of God' Conclusion John Charle Hagee | John Hagee 2015 | John Charle Hagee 2015 | John Hagee 2014 | John Charle Hagee 2015 | John Hagee Sermons | John Hagee Sermons 2015| John Hagee new | John Hagee _ ... From: John Hagee All Video 2015 Views: 0 0 ratings Time: 27:32 More in People & Blogs
          • Matters of Size: Discovering Penis Enlargement
            Matters of Size: Discovering Penis Enlargement http://naturalpenisenlargement.mvxz.com Natural Penis Enhancement Natural Penis Enhancement is using manual workouts to increase the size of the penis. This technique of penis enlargement need. From: naturalpenisenlargement Views: 0 0 ratings Time: 10:50 More in Howto & Style
          • Matters of Size: Discovering Penis Enlargement
            Matters of Size: Discovering Penis Enlargement http://penisgrowthchannel.mvxz.com Penis Enlargement products: Are They Really Much better than Surgery? The most common penis enlargement products include 4 types of products: supplements,... From: naturalpenisenlargement Views: 0 0 ratings Time: 10:50 More in Howto & Style
          • Dad found hanged after discovering his daughter posing NUDE in Playboy magazine
            Dad found hanged after discovering his daughter posing NUDE in Playboy magazine Dad found hanged after discovering his daughter posing NUDE in Playboy magazine. From: gyan61 Views: 0 0 ratings Time: 01:20 More in Entertainment
          • Discovering Christ in the Old Testament
            Discovering Christ in the Old Testament Is the Bible primarily about you? Or is it about someone or something else? Discover how the Bible is really telling one big story and how the main character of the entire Bible is Jesus. Join... From: A Ransomed Mind Views: 0 0 ratings Time: 01:11:10 More in People & Blogs
          • Discovering the Waterfront Portland Tour - Silverstein
            Discovering the Waterfront Portland Tour - Silverstein Silverstein playing Bleeds No More. Discovering the Waterfront 10-Year Anniversary Tour Hawthorne Theater Portland, OR 1/26/15. From: Carinasan Views: 0 0 ratings Time: 03:17 More in Music
          • DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary)
            DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary) DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary) discovering the black bear - discovery animals nature (documentary). thanks for watching. animal animals wildlife sea ... From: My Collene Views: 0 0 ratings Time: 03:43:24 More in People & Blogs
          • Discovering the Waterfront Portland Tour - Silverstein
            Discovering the Waterfront Portland Tour - Silverstein Silverstein playing The Artist. Discovering the Waterfront 10-Year Anniversary Tour Hawthorne Theater Portland, OR 1/26/15. From: Carinasan Views: 0 0 ratings Time: 02:54 More in Music
          • Discovering Your Tarot Birth Cards
            Discovering Your Tarot Birth Cards From: Laura Elisebeth Views: 0 0 ratings Time: 01:09:39 More in Education
          • Discovering Your Unique Selling Proposition with Hoss Pratt and Toby Salgado
            Discovering Your Unique Selling Proposition with Hoss Pratt and Toby Salgado From: Super Agents Live Views: 0 0 ratings Time: 01:04:25 More in Entertainment
          • Discovering the Waterfront Portland Tour - Silverstein
            Discovering the Waterfront Portland Tour - Silverstein Siverstein playing Smashed Into Pieces. Discovering the Waterfront 10-Year Anniversary Tour Hawthorne Theater Portland, OR 1/26/15. From: Carinasan Views: 0 0 ratings Time: 03:16 More in Music
          • Discovering 5 seconds of summer + getting drunk
            Discovering 5 seconds of summer + getting drunk Me reacting to 5sos for the first time! and drinking wine! enjoy! From: Random Tania Views: 4 0 ratings Time: 07:36 More in Comedy
          • DISCOVERING THE BARRACUDA - Discovery Animals Wildlife (full documentary)
            DISCOVERING THE BARRACUDA - Discovery Animals Wildlife (full documentary) Discovering the Barracuda (full documentary). thanks for watching. animal animals wildlife sea marine discovery planet history life science technology tech learning education earth planet... From: EarthLifeDocumentaries Views: 0 0 ratings Time: 44:35 More in Education
          • Discovering the barracuda Animals/Wildlife/Nature (documentary)
            Discovering the barracuda Animals/Wildlife/Nature (documentary) Discovering the barracuda Animals/Wildlife/Nature (documentary) the barracuda - animals wildlife nature (documentary). thanks for watching. animal animals wildlife sea marine discovery planet... From: Cherl Swett Views: 0 0 ratings Time: 03:25:44 More in People & Blogs
          • ANCIENT ASTRONAUTS: Ice Age Civilizations and Atlantis - Underwater Archeology - FEATURE F
            ANCIENT ASTRONAUTS: Ice Age Civilizations and Atlantis - Underwater Archeology - FEATURE F ANCIENT ASTRONAUTS: Ice Age Civilizations and Atlantis - Underwater Archeology - FEATURE FILM Scientists are now discovering at the bottom of the earth's oceans evidence of ancient advanced... From: Lura Swett Views: 0 0 ratings Time: 01:57:25 More in People & Blogs
          • Discovering Your Why
            Discovering Your Why Discovering Your Why. From: Stacee Morales Views: 0 0 ratings Time: 00:00 More in Entertainment
          • DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary)
            DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary) discovering the black bear - discovery animals nature (documentary). thanks for watching. animal animals wildlife sea marine discovery planet history life sc The American Black Bear (full... From: Kecca Pgeele Views: 0 0 ratings Time: 03:17:02 More in Science & Technology
          • Discovering Your Dreams
            Discovering Your Dreams Women's Retreat. From: Chuck Towersey Views: 6 0 ratings Time: 03:10 More in Education
          • Silverstein - Discovering the Waterfront
            Silverstein - Discovering the Waterfront In honor of their ten-year anniversary of this album and their amazing tour they've put together for it. From: Vaughn Renner Views: 0 0 ratings Time: 04:46 More in Music
          • Baby Einstein Playlist 2014 Discovering Shapes & Language Nursery Full Movie Long!
            Baby Einstein Playlist 2014 Discovering Shapes & Language Nursery Full Movie Long! Baby Einstein Playlist 2014 Discovering Shapes & Language Nursery Full Movie Long! From: Baby Einstein Views: 0 0 ratings Time: 55:45 More in Entertainment
          • Baby Einstein Baby Neptune Discovering Water
            Baby Einstein Baby Neptune Discovering Water Baby Einstein Baby Neptune Discovering Water. From: Baby Einstein Views: 0 0 ratings Time: 25:06 More in Entertainment
          • DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary)
            DISCOVERING THE BLACK BEAR - Discovery/Animals/Nature (documentary) discovering the black bear - discovery animals nature (documentary). thanks for watching. animal animals wildlife sea marine discovery planet history life sc The American Black Bear (full... From: Kecca Pgeele Views: 0 0 ratings Time: 03:53:09 More in Science & Technology
          • Discovering the barracuda Animals/Wildlife/Nature (documentary)
            Discovering the barracuda Animals/Wildlife/Nature (documentary) Discovering the barracuda Animals/Wildlife/Nature (documentary) the barracuda - animals wildlife nature (documentary). thanks for watching. animal animals wildlife sea marine discovery planet... From: Cherl Swett Views: 0 0 ratings Time: 03:29:06 More in People & Blogs
          • Discovering Space - Oculus Rift - ¬°Explosi√≥n Mental!
            Discovering Space - Oculus Rift - ¡Explosión Mental! Sin duda lo mejor que he probado para Oculus Rift. He probado demos de miedo, de montañas rusas, shooters... Todo mejor o peor hecho, mejor o mayor inmersivo, pero esta demo es. From: Dangual Games Views: 7 5 ratings Time: 12:32 More in Science & Technology

          •      Related on Wikipedia




























             

            Powered free by PHPmotion