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Abstract: Novel amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives were prepared from ethyl 4-phenylsulfonyl-2-( 2'-phenylsulfonyleth yl)-2-cyanobutyrate (1), ethyl 4-arylsulfonyl-3-ary l-2-cyanobutyrate (7) and ethyl 4-arylmethylsulfonyl -3-aryl-2-cyanobutyr ate (8). The lead molecules have been tested for their antimicrobial activity and antioxidant property.