Tissue atenolol levels following chronic beta-adrenoceptor blockade using oral atenolol in dogs.
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PubMed
(0) (0 Votes)Views: () Date: (1986-4-1) Pages: () -
Author: J McAinsh
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Abstract: Tissue atenolol concentrations are high following chronic continuous beta-adrenoceptor blockade in dogs. Furthermore, significant concentrations of this poorly lipid soluble drug are found within the central nervous system after chronic dosing. It is suggested that all beta-adrenoceptor blocking agents may enter the central nervous system in significant and sufficient quantities to account for a central antihypertensive action of this group of compounds. Sequestration of beta-adrenoceptor agents in the CNS or other tissues may account for other clinically observed effects including adaptive effects.
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