Relationship between creatinine clearance and plasma homocysteine levels in predialytic chronic renal failure patients.

Abstract:  In order to determine the relationship between homocysteine levels and renal function, a cross-sectional study was carried out at out-patients clinic division of Nephrology and Hypertension Sanglah General Hospital Denpasar. Patients selected for the study were those with creatinine levels of 1.5-8.0 mg/dl aged 18 to 60 years. All eligible patients were examined for serum creatinine levels. At the same time blood samples were drawn for the examinations of total fasting Homocysteine levels. Creatinine clearance was calculated by Cockcroft-Gault formula, serum creatinine levels were examined by Jaffe method and total fasting Homocysteine levels were examined by fluorescence polarization immunoassay method (FPIA) method. If fasting plasma homocysteine levels were correlated with some related factors including creatinine clearance, reciprocal creatinine levels, age and gender, it was shown that only age (r=0.39, p=0.04) and creatinine clearance (r=0.39, p=0.04) had moderate and significant correlation with homocysteine levels. If both creatinine clearance and age as independent factors were correlated with fasting plasma homocysteine levels using multiple regression analysis, it was shown that both variable had strong (r=0.5) and significant relationship (p=0.03), yielding regression equations: Hcy (mmol/L) = -0.20 Cct (ml/mnt) + 0.21 age (ys) + 12.8. In conclusions, in patients with pre-dialytic chronic renal failure both creatinine clearance and age are strong predictors to plasma homocysteine levels.