How to activate p53.


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    Field: Medicine  DOWNLOAD  BOOKMARK REPORT
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    • Author:  T Caspari  

    • Abstract:  The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20.

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